I know that's a loaded question considering where our illness stands in the medical community but where is the merit for this being beneficial to everyone? I'm under the understanding that Freddd doesn't take SNP's into consideration, isn't that the most important part? Because of my SNP's I'm told to take hydroxyl b12 instead of methyl but I decided to try methyl instead based on Freddd's protocol and did not respond well at all. I'm not talking "start up reactions", I'm talking uncontrollable levels of adrenaline with even the slightest amount of mb12, presumably because of my CBS and COMT mutations. With .25 mg I didn't sleep for 2 days and after a couple weeks of this my health has declined considerably due to the sleep loss and an out of control OCD, all due to the adrenaline. Dr Cheney, Rich Vank and Amy Yasko all say that hydroxyl b12 is the best source for some people but Freddd discredits this. Is there merit to that?