Thanks for digging that one out. I had seen it and of course it commits the schoolboy error of confusing correlation with causation (what the ???? are reviewers doing?). Compare this with the pregnancy and pain/deconditioning study DQ posted which looked at a time sequence and found that in fact pain came before deconditiong. very belated edit: For completeness, it's worth pointing out that the 1998 Lorenzo failed to used properly sedentary healthy controls so the differences between controls and patients tell us nothing. Like you I have found surprisingly little evidence linking decon to symptoms - and actually haven't seen any evidence that atrophy causes pain and fatigue either, so rest easy in your bed... Think the NASA review of decon of healthy volunteers will be key but it's a bit of a monster and I don't have the energy right now.