Hi I'm new to this forum and CFS in general having been diagnosed in May of this year, with symptoms starting in Feb 2012. I am on Valcyte for high HHV-6 and EBV, LDN, and Remeron for sleep. I also have hashimotos and recently (8/13) had surgery for a thyroid nodule that turned out to be cancer. I also take a good number of supplements. Anyway, I want to try Rich's simplified methylation protocol from 2012 and plan to get the 23 and me genetic tests, but I don't have a way to easily get the health diagnostics meythalation panel. My CFS MD doesn't really believe methylation to be helpful and the rest of my MDs aren't believers in CFS at all. I guess I would have to find a functional medicine MD who would agree to to the testing, but they all cost a lot of money and I'm not sure any of the few around me know anything about the topic. So my question is how bad would it be to start the protocol without further testing? My b12 and folate serum levels are usually high--without any supplementation--but I'm not sure that that really means anything if they are not getting into my cells. My major issues continue to be PEM, general fatigue, insomnia, muscle soreness, eye pain, joint pain etc. Thanks for any help offered!