drob31
Senior Member
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Is Sam-E better, or just different because it provides Sam?
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Is Sam-E better for methylation than methylfolate or methyl b12?
- Thread starter drob31
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Learner1
Senior Member
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No, you need all the methylation nutrients. If you just take SAMe, you'll likely end up with too high homocysteine as you'll be missing the needed cofactors to recycle homocysteine back to methionine.