It really seems like methylation might be my problem. But I live in a slightly-remote area and cannot travel. My local doc is very willing to prescribe tests, meds, etc. that I research and suggest, but she does not have any special knowledge about this stuff. Testing is also difficult to access here. It sometimes takes up to 3 years for tests she orders to get done, though 3 weeks to 2 months is more typical. We cannot, for example, order tests for a specific day and count on the blood draw being done that day... or even that week. And definitely no emergency tests. From what I've tried and read so far, it seems like experimenting with methylation frequently leads to abrupt, intense onsets of unexpected symptoms. You folks who are doing it, do you all have doctors and testing facilities that you can access 24/7, and is that what is needed? And, if so, do any of those docs work with patients over skype, patients who cannot travel? Thanks for your help . I really want to do this, but am not sure how to proceed.