I ask because, well, im on fairly high doses of everything now and i dont feel a damn thing. Im on 22.5 mg methylfolate, 15-20 mg mb12 and 1000 mg LCF per day and i just dont feel anything from it. Each nutrient gave me a little jitteryness when i first started but i was able to titrate up quickly. Im going to add TMG and see if that does anything but im already taking a lot of choline. And no, no NAC or glutathione or anything. Just my methyl supps and cofactors.