I have been so engrossed in getting my protocol ironed out that it never occured to me to wonder if this sort of supplementing is a forever thing? Will I have to supplement for the rest of my life or will my methyl cycles "take over," eventually? For me, first it was suspected I had a b12 def. due to many years as a vegan, so I supplemented.. and then I started digging more and found out I am compound hetero for the two big deal MTHFR's. So, folate is a problem too. But I guess I am confused still... am I B12 deficient? Can you be one without other? Can these things correct over time or can I look forward to taking a gazillion supplements until the end of time?