In the front page article Dr. Peterson talks about sickness behavior. The evolved function of sickness behavior is to act as an energy-conserving, risk-minimizing, immune-enhancing state appropriate for a body mounting a short-term, all-out attack on an invading micro-organism (Hart, 1988; Kent et al, 1992). The theory is that in M.E. sickness behavior, which is designed to be a short-term state, is stuck in the "on" position perpetually. If we were to take a healthy cohort and do the tests on them (the tests that richvank suggests we do prior to going on his protocol) and repeated those tests on these normal people at various stages of the flu through to recovery what would we see? Would the normal people's test results with the flu temporarily look like us? How about the mitochondrial tests that Dr. Myhill uses? It's possible that with rituximab, what's left of the immune system is unable to produce sickness behavior. All doctors treating our symptoms say that our bodies seem to "want" these symptoms. Fighting the results is difficult since the body is trying to do something. Rituximab blows away the system with a shotgun.