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Is folate necessary?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by celtic426, May 20, 2016.

  1. celtic426

    celtic426

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    Taking 400mg methy-folate makes me anxious and puts me on edge.

    Homozygous for MTHFR C677T

    Taking:

    Adeno and Hydrox B12 (no effect from methyl-b12)
    B-minus from Seeking Health (a mulit B vitamin)
    Magnesium ~400 mg/day

    I tried:
    TMG - made me tired and indifferent
    Phosphatidyl choline - tired

    Is it bad to supplement B12 and a mulit-B without the inclusion of a folate supplement? Will it throw things off balance?

    Thanks
     
  2. PeterPositive

    PeterPositive Senior Member

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    What brand of folate are you using?
    I ask because I do well on Metafolin while I get anxiety from almost all other alternative forms (e.g. Quatrefolic etc...) at the same dosage.

    Also, if you just started out you may need to pace yourself and not start at 400mcg but maybe at 1/4th or 1/8th of that and see if you can build your tolerance over time.
     
  3. celtic426

    celtic426

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    Thanks for that.

    Didn't realize metafolin was a different kind (I was using Quatrefolic).
     
  4. PeterPositive

    PeterPositive Senior Member

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    There are three forms: Metafolin which is a trademark of Merck, Quatrefolic and Extrafolate by Gnosis.
    The only supplement brand that uses Metafolin is Solgar, as far as I know.

    While they should all work pretty much the same, people here have reported different effects (and side effects) using difffernt forms. I find the two alternatives stronger but in a strange way and I always end up with too much anxiety. Metafolin never does that. Don't ask me why :)
     
    celtic426 likes this.
  5. celtic426

    celtic426

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    How about folinic acid. Would that be worth looking into as well?
     
  6. ahmo

    ahmo Senior Member

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    Northcoast NSW, Australia
    You might find some answers in Caledonia's signature, many links re engaging in methylation protocol.
     
  7. caledonia

    caledonia

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    Cincinnati, OH, USA
    Hi, just happened to see this. Check my signature link for Start Low and Go Slow and Roadblocks to Successful Methylation.
     
  8. PeterPositive

    PeterPositive Senior Member

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    Being C677 homozygous (as I am) methyl-folate would probably be best, as it doesn't need any conversion steps.
     
  9. Critterina

    Critterina Senior Member

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    Arizona, USA
    And the conversion step to convert folinic is exactly the one affected by MTHFR C677T. So I'd not waste my time on that. (I am C677T -/- and A1298C +/- - not a very bad set at all, but I could not stay awake to save my life after taking folinic. No telling why - probably something else.)
     
    Valentijn and PeterPositive like this.

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