• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To become a member, simply click the Register button at the top right.

Is depression a kind of allergic reaction?

Denise

Senior Member
Messages
1,095

Interesting article @minkeygirl. The article also points to a youtube video (
) and an article (http://www.biolmoodanxietydisord.com/content/4/1/10).

The biolmoodanzietydisord article (haven't read it yet) has some interesting references including:

Hornig M, Briese T, Licinio J, Khabbaz RF, Altshuler LL, Potkin SG, Schwemmle M, Siemetzki U, Mintz J, Honkavuori K, Kraemer HC, Egan MF, Whybrow PC, Bunney WE, Lipkin WI: Absence of evidence for bornavirus infection in schizophrenia, bipolar disorder and major depressive disorder.

VanElzakker MB: Chronic fatigue syndrome from vagus nerve infection: a psychoneuroimmunological hypothesis. Med Hypotheses 2013, 81:414-423
 

heapsreal

iherb 10% discount code OPA989,
Messages
10,099
Location
australia (brisbane)
interesting as there is another thread discussing inflammation in neurological disorders. Although many cfsers cant tolerate antidepressants, they are prescribed to people with neurological disorders for not only depression but also for there anti inflammatory effects.
 

Bob

Senior Member
Messages
16,455
Location
England (south coast)
I think it's a very good article apart from this sentence which seems a bit out of place: "...it starts to look as if depression is a kind of allergy to modern life – which might explain its spiralling prevalence all over the world as we increasingly eat, sloth and isolate ourselves into a state of chronic inflammation."

There's no mention of potential genetic propensity which I personally think might play a major role for many people with depression and bi-polar. But inflammation and infection might still be a key to treatment, even in those with a strong genetic propensity.
 
Last edited:

Research 1st

Severe ME, POTS & MCAS.
Messages
768
Certainly eating a high calorie diet and becoming obese, will only worsen inflammation.

Perhaps one treatment of depression could be a form of agreed fasting, or periods of such to get weight down to levels where estrogen doesn't dominate in men, never mind women.
 

jimells

Senior Member
Messages
2,009
Location
northern Maine
I think it's a very good article apart from this sentence which seems a bit out of place: "...it starts to look as if depression is a kind of allergy to modern life – which might explain its spiralling prevalence all over the world as we increasingly eat, sloth and isolate ourselves into a state of chronic inflammation."

There was a discussion of this on CBC Radio this morning. My reaction was, "Well, yes, I *am* allergic to society," And I experience a very bad reaction to living in a society where half the population thinks that torturing Evildoers is just fine, along with smashing any society that fails to follow US diktats.

I suspect that biomedical researchers will eventually find that depression is a symptom caused by various diseases. For one subgroup, "demoralization" would be a better term than "depression". I'm thinking of the demoralization caused by alienation, feelings of powerlessness, and lack of social supports, such as experienced by so many of us.