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Is CFS truly associated with haplogroups or mtDNA single nucleotide polymorphisms?

mango

Senior Member
Messages
905
Is chronic fatigue syndrome truly associated with haplogroups or mtDNA single nucleotide polymorphisms?

Josef Finsterer, Sinda Zarrouk-Mahjoub

Journal of Translational Medicine 2016 14:182
Letter to the Editor

With interest we read the article by Billing-Ross et al. [1] about 193 patients with chronic fatigue syndrome (CFS) diagnosed according to the Fukuda or Canadian Consensus criteria and undergoing sequencing of the mtDNA, the DePaul Symptom questionnaire and the Medical Outcome Survey Short Form-36. The study showed that CFS is associated with mtDNA haplogroups J, U and H, that 8 mtDNA single nucleotide polymorphisms (SNPs) were associated with 16 symptom categories, and that three haplogroups were associated with six symptom categories [1]. We have the following comments and concerns. [...]
Open access

http://translational-medicine.biomedcentral.com/articles/10.1186/s12967-016-0939-0