The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Is CFS hereditary from the father/male?

Discussion in 'General ME/CFS Discussion' started by md55, Oct 11, 2015.

  1. md55

    md55

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    Hello everyone. I was wondering if there is any concrete evidence on whether the male/father is capable of passing on CFS to thier children?

    Assuming CFS can be passed on, does it lay dormant until it's triggered or are the children born with CFS symptoms?

    For those that have had children, can you share your stories of how they're doing?
     
  2. Research 1st

    Research 1st Severe ME, POTS & MCAS.

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    Short answer:

    No. There is no evidence, and naturally no concrete evidence at all.

    Long answer:

    Because of the Fukuda diagnostic criteria, (self reported fatigue and 4 or more non proven symptoms) CFS can never exist as transmittable disease or genetic disorder.

    CFS is a clinical diagnosis, like a headache or pain. These may or may or not exist, it's what the person reports. A doctor cannot 'test' for these, because CFS 'tests' are exclusionary not based on inclusion.

    But...people with vary reasons for ill health diagnosed with CFS exists. People's suffering is real, so they are sick and need researching biomedically.

    But then we come back to square one. The people who need researching, no one can ever tell who 'they' are, as no one needs to demonstrate illness at time of diagnosis. Due to this people will present with many reasons for being sick. These range from active infections, autoimmunity, neurological, allergic to cardiac to hormonal, to circulatory to psychosomatic.

    Thus it's impossible to answer the question if 'CFS' is transmittable.

    You can however notice than may infections are passed on, and thus if the male is impregnating the female, then it's not impossible the female is then infected and her baby becomes so too. On that basis, if you can prove the same strain of infection (e.g. Lyme) or a man with CFS who then gives it to his sexual partner, and she wasn't sick before and/or their baby wasn't sick before, the on this hypothetical basis, a person's 'CFS' (that is then a misdiagnosis because of the diagnostic criteria!) is hereditary.

    An infection, be it bacterial, viral or retroviral can be passed on by either sex.

    If this comes to light in 'CFS' at a rate of 0.1% or 10% or 25% we shall have to wait and see just how widespread non tick based Lyme actually is (the majority of chronic lyme patients have their diagnosis denied and their official diagnosis was, or is CFS).

    Read this for ideas:
    https://www.lymedisease.org/lyme-sexual-transmission-2/

     
    Snow Leopard likes this.
  3. Hip

    Hip Senior Member

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    Can you explain how you managed to conclude that CDC 1994 criteria would exclude a diagnosis of CFS if that CFS condition involved genetic factors?
     
  4. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    Agreed.

    It might or might not be possible to inherit risk factors. These might or might not be heritable from the father. There is some anecdotal claim that its more often seen in families following a mother-daughter pattern, but the problem here is that ME is more common in women anyway, and this may confound any seeming gender bias in inheritance risks.

    In other words, we might guess but in no way is there concrete evidence.

    I do wonder if ME in men is slightly different from ME in women though, though this is probably just disease expression being different This is an entirely different question to the inheritance angle. Its also not answered.

    There are some old twin studies that suggest some component of ME is inheritable, probably a risk factor, but nothing definitive.

    The closest we come to heritable risk factors would be research into things like EDS (which appears to be often heritable) and various methylation genes, in which polymorphisms are more common in CFS and possible ME patients.
     
    SOC likes this.
  5. unto

    unto Senior Member

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    certain that, everyone can transmit ME / CFS to a child, not through genes DNA but simply because ME is an infectious disease
     
  6. john66

    john66 Senior Member

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    When my son was born, I was sure he inherited CFS from me. As it turns out he has Prader Willi Syndrome. According to a very smart genetecist, she said mitochondrial DNA comes from the mother. I still think there are too many unknowns to say yes or no definitavely
     
    Valentijn likes this.

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