The power and pitfalls of omics part 2: epigenomics, transcriptomics and ME/CFS
Simon McGrath concludes his blog about the remarkable Prof George Davey Smith's smart ideas for understanding diseases, which may soon be applied to ME/CFS.
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is celebrex as bad for gut as older COX inhibitors?

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by ebethc, Feb 9, 2017.

  1. ebethc

    ebethc Senior Member

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    I thought celebrex was okay on gut; older NSAIDS are, of course, not... Today someone told me that it's just as bad... Does anyone know?
     
  2. adelheid55

    adelheid55 Senior Member

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    I take it since many years but not permanently. Just when muscles or head aches. I have had serious problems with other NSAIDs like Gastritis but Celebrex is OK for me.
     
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  3. ukxmrv

    ukxmrv Senior Member

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    I do well on Celebrex (no heart or gut problems)
     
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  4. Mohawk1995

    Mohawk1995 Senior Member

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    Celebrex was the only NSAID our son could take during his years of suffering with ME/CFS. He had significant gut issues with any other one. Did not take it all the time, but went through periods where he took minimal doses daily for months.
     
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  5. alex3619

    alex3619 Senior Member

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    In theory Celebrex should not do much damage to the gut. It is in a class of drugs called COX-2 inhibitors. I would not say it does no damage at all, but it would be much less than older NSAIDs. Now if there is specific data to the contrary I think we should be asking where is the data?

    I do not think any NSAID is safe in high doses for long periods. However I think, gut issues aside, there are some that are much safer. IIRC Naproxen is associated with increased life expectancy, and its one of a few not associated with decreased life expectancy. However Naproxen is still going to damage the gut lining. These drugs do this by inhibiting eicosanoid synthesis, and without these eicosanoids the gut lining is not rapidly healed

    I have used Celebrex though very sparingly. Indeed the packet usually expires before it is even a quarter used. I have noticed no gut issues.
     
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  6. ahmo

    ahmo Senior Member

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    I used Celebrex for some months. When I quit, I got heart palps. Please be cautious.
     
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  7. ebethc

    ebethc Senior Member

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    it's not helping that much anyway... so far... thanks
     
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