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Is Cadmium a cause of ME/CFS?Article in Medical Hypothesis Journal

Discussion in 'Latest ME/CFS Research' started by Gamboa, Jul 18, 2012.

  1. Gamboa

    Gamboa Senior Member

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    Below is the abstract from an on-line journal called Medical Hypotheses. The researchers are from the University of Florence in Italy.

    Article in Press
    Could cadmium be responsible for some of the neurological signs and symptoms of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
    Received 24 May 2012; accepted 17 June 2012. published online 16 July 2012.
    Corrected Proof

    Abstract

    According to the World Health Organization, Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a neurological disease characterized by widespread inflammation and multi-systemic neuropathology. Aetiology and pathogenesis are unknown, and several agents have been proposed as causative agents or as factors perpetuating the syndrome. Exposure to heavy metals, with particular reference to mercury and gold in dental amalgams, has been considered among the triggers of ME/CFS. Here we hypothesize that cadmium, a widespread occupational and environmental heavy metal pollutant, might be associated with some of the neurological findings described in ME/CFS. In fact, ME/CFS patients show a decrease of the volume of the gray matter in turn associated with objective reduction of physical activity. Cadmium induces neuronal death in cortical neurons through a combined mechanism of apoptosis and necrosis and it could then be hypothesized that cadmium-induced neuronal cell death is responsible for some of the effects of cadmium on the central nervous system, i.e. a decrease in attention level and memory in exposed humans as well as to a diminished ability for training and learning in rats, that are symptoms typical of ME/CFS. This hypothesis can be tested by measuring cadmium exposure in a cohort of ME/CFS patients compared with matched healthy controls, and by measuring gray matter volume in un-exposed healthy controls, exposed non-ME/CFS subjects, un-exposed ME/CFS patients and exposed ME/CFS patients. In addition, we hypothesize that cadmium exposure could be associated with reduced cerebral blood flow in ME/CFS patients because of the disruptive effects of cadmium on angiogenesis. In fact, cadmium inhibits angiogenesis and low global cerebral flow is associated with abnormal brain neuroimaging results and brain dysfunction in the form of reduced cognitive testing scores in ME/CFS patients. This hypothesis can be tested by measuring cerebral cortex blood flow in un-exposed healthy controls, exposed non-ME/CFS subjects, un-exposed ME/CFS patients and exposed ME/CFS patients. If our hypothesis is demonstrated correct, the consequences could affect prevention, early diagnosis, and treatment of ME/CFS. Implications in early diagnosis could entail the evaluation of symptoms typical of ME/CFS in cadmium-exposed subjects as well as the search for signs of exposure to cadmium in subjects diagnosed with ME/CFS. Nutritional supplementation of magnesium and zinc could then be considered, since these elements have been proposed in the prophylaxis and therapy of cadmium exposure, and magnesium was demonstrated effective on ME/CFS patients’ symptom profiles.
  2. Gamboa

    Gamboa Senior Member

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  3. Crux

    Crux Senior Member

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    Thanks for this link, Gamboa;

    I do believe that cadmium accumulation can be a factor in CFS/ME. I've read that it can fill zinc receptors and disrupt metabolism.

    I've had alot of exposure to cadmium, being an ex-smoker, and one who has used many cadmium pigments with bare hands.

    I believe I've also been zinc deficient most of my life.

    I'm going to increase magnesium again. I was having trouble with it for a while, but that may have been due to the zinc def.
  4. liverock

    liverock Senior Member

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    Cadmium ticks quite a few boxes where CFS is concerned.

    Neurotransmitters such as acetyl choline,catacholamines and GABA are all affected by cadmium.
    Cadmium also inhibits the methylation of phospholipids which interferes with cell membranes

    On energy production, glutathione reductase and Krebs cycle enzymes pyruvate and a-ketoglutarate dehydrogenese
    are all affected.

    http://www.arltma.com/Articles/CadmiumToxDoc.htm
  5. Shell

    Shell Senior Member

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    That's interesting. I've wondered what the environmental factors are for a while. The fact that ME/cfs has cluster outbreaks would indicate something environmental and the fact of the bizarrely high number of us being either teachers or nurses has to be a factor.
    In the early 80's just as the new cluster outbreaks began most of us nurses and teachers were living in a fog of other people's smoke, even when we weren't smokers. I always remember how bad my morning sickness was with my oldest because I was working on a smoke fogged ward. Most of us worked long hours as well, especially back then when a nurses wage barely covered the bills.

    The only other exposure to cadmium I can think of for me was in paint. Hmmm. Should have got to grips with watercolour after all perhaps.

    I'm trying to up my magnesium intake and zinc. (with coQ10). Worth a try.
  6. In Vitro Infidelium

    In Vitro Infidelium Guest

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  7. merylg

    merylg Senior Member

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  8. Sushi

    Sushi Moderator and Senior Member Albuquerque

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    A bit more info:

    Could cadmium be responsible for some of the neurological signs and symptoms
    of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

    Stefania Pacini, Maria G. Fiore, Stefano Magherini, Gabriele Morucci, Jacopo J.V. Branc, Massimo Gulisanoa, Marco Ruggiero

    Department of Anatomy, Histology and Forensic Medicine, University of Firenze, Viale Morgagni 85, 50134 Firenze, Italy

    Department of Experimental Pathology and Oncology, University of Firenze, Viale Morgagni 50, 50134 Firenze, Italy
    WillowJ and merylg like this.
  9. WillowJ

    WillowJ Senior Member

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    http://www.osha.gov/SLTC/cadmium/
    merylg likes this.
  10. liverock

    liverock Senior Member

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    Its not just among industrial workers where cadmium is absorbed. Cadmium is also used in phosphate fertilisers and animal feed and is absorbed in vegetables as well as animal flesh. Cadmium is lodged in animals liver and kidneys and some is excreted in urine and feces and this is also used as a fertiliser in manure, further increasing cadmium levels in vegetables.

    Nobody really knows the full extent of cadmium levels in humans but it is said to have a half life of 30 years which means a steady build up and increase over a lifetime.
    Cadmium is more dangerous than mercury as it tends to replace zinc in over 300 enzymes, causing malfunctions in energy cycles such as the Krebs cycle causing increased fatigue.

    It also lowers acetylcholine levels as well as interfering with other neurotransmitters. As it replaces zinc it also damages arteries causing arteriosclerosis and weakening the heart muscle.

    http://www.arltma.com/Articles/CadmiumToxDoc.htm
  11. Antares in NYC

    Antares in NYC Senior Member

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    Is there an effective way to test for cadmium levels?
    More importantly, how do you chelate cadmium from your system?
  12. Lou

    Lou Senior Member

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    Pectasol Detox formula, chlorella, FIR sauna, to name a few.
  13. IreneF

    IreneF Senior Member

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    I just don't see how I could have been exposed to cadmium. Plus there would have to be an occupational relationship; how many of us worked in manufacturing and construction, for example?
  14. tyson oberle

    tyson oberle

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    So is there an effective way to test for excessive cadmium levels?
  15. A.B.

    A.B. Senior Member

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    Everyone is exposed to cadmium through diet and air. The body simply excretes it. If there is a problem with excretion not functioning correctly for whatever reason, then a person would accumulate toxic levels of cadmium over the years.
  16. liverock

    liverock Senior Member

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