Hello all I've been in contact with someone from the b12oils.com website. I have been discussing the difficulties that I have had with taking the methylb12 and methylfolate. They seem to think that the side effects come from an under functioning MAOA enzyme due to a lack of vitamin B2. They have told me that in order to tolerate b12/folate, one would want to take B2 for up to a month before trying to take b12/folate in order to get the MAOA enzyme working in order to clear neurotransmitters. They mention COMT but really put emphasis on MAOA. So there's another theory to add to the pile. Any thoughts, advice or experiences??