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Irritable bowel syndrome and chronic fatigue six years after Giardia infection...

Discussion in 'Latest ME/CFS Research' started by Bob, Aug 15, 2014.

  1. Bob

    Bob

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    This paper refers to Giardia infection and chronic fatigue rather than CFS. I thought it might be of interest to some members.


    Irritable bowel syndrome and chronic fatigue six years after Giardia infection: a controlled prospective cohort study.
    Hanevik K, Wensaas KA, Rortveit G, Eide GE, Mørch K, Langeland N.
    Clin Infect Dis. 2014 Aug 12. pii: ciu629. [Epub ahead of print]
    http://www.ncbi.nlm.nih.gov/m/pubmed/25115874/

     
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  2. SB_1108

    SB_1108 Senior Member

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    I developed CFS about 8 years after I developed IBS - so I wonder how the results would have been different factoring in more time. And actually I had the stomach flu about 4 months before the onset of CFS... I've always felt like that was a catalyst for me.
     
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  3. Martial

    Martial Senior Member

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    Small intestine bacterial overgrowth plays for a large portion of IBS cases. Wonder how much of a problem that is for some here.

    edit* Just read that the parasitic infection targets the small intestine, with cycles of life that includes cysts... Very interesting. Seems like these people still have an active infection that was not properly treated.
     
  4. Dolphin

    Dolphin Senior Member

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  5. Dolphin

    Dolphin Senior Member

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    Fatigue was designed as a score of 4 or more on the Chalder fatigue questionnaire (bimodal scoring, 11-item version).

    Unfortunately, they didn't try to assess CFS.

    They also looked at severe fatigue which was a score of 23 or more on the Chalder fatigue questionnaire (likert scoring, 11-item version). One might guess that a reasonable percentage of these have CFS or a CFS-like condition.

    At 3 years:
    Giardia exposed: 15.1%
    Controls: 2.1%

    At 6 years:
    Giardia exposed: 9.0%
    Controls: 2.6%
     
  6. Dolphin

    Dolphin Senior Member

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    They discuss the issue of chronic infection:
    So it doesn't look like it's an issue (but I'm no expert)
     
  7. Dolphin

    Dolphin Senior Member

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    I thought it was interesting that those who has fatigue at 3 years in the post-giardia group were more likely to have fatigue at 6 years compared to the control group:
    If one thinks of CFS research, there is some discussion on predictors of response/non-response or recovery/non-recovery. In a mixed fatigue group, this suggests that those whose followed an infection are less likely to recover than a mixed group (which presumably includes many whose fatigue wasn't due to an infection). This would be a different predictor to some of the psychological/biopsychosocial predictors that are mentioned sometimes.
     
  8. goldberg

    goldberg

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    Very interesting,
    I developed IBS after an intestinal infection during a trip and CFS after four years of IBS,
    perhaps a Giardia infection modifies our microbiome long term?
     
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