The Real ME: A Stock Photography Resource for the Media
We’ve all seen them in the news stories about ME/CFS: the guy in a suit at the office, yawning; the beautiful woman sitting at her desk with her immaculate make-up and elegantly coiffed hair, hand to her head and looking slightly pained.
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  1. annabettina


    Hi...first let me say am new to this subject of methylation.

    Ok, had a dr to test me and she found this: MTHFR: Genotype C/T(C677T) and A/C (A1298C).
    She prescribed l methylfolate...Deplin 15 mg but I didn't feel good on this, felt worse (have treatment resistant depression). Now doing Life Extension brand and only 1 mg. Feel somewhat better. Also doing some MB12 Life Extension brand.

    Have a lot of questions but here is my main one...

    Have read on the Internet forums that those with this MTHFR thing may have a hard time handling metals like iron, copper, zinc. I did test weird on my iron tests...ferritin low normal (also had inflammation at that time...poison ivy) but total iron was a couple of pts over normal, iron binding capacity upper normal, and % sat upper normal. Had not taken any iron for 48 hrs before the test (two days earlier had taken a multi vit and min that happen to have iron...because of my husband mainly I purchase vit/mineral supps without iron) but taking a lot of vit C when tested.

    As for MTHFR and folate, I'll pass this on...

    Years ago when my folic acid serum test was done, it was super high, elevated even I hadn't taken any folic acid supplements or eaten before the test. Now having learned about this MTHFR thing I better understand the reason for that elevation...I wasn't breaking down the folic into l methylfolate, the active component.

    Thank you So Much for taking the time to read this,


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