Ecoclimber
Senior Member
- Messages
- 1,011
@ Ren
I don't know if you had a chance to slog through the Research Advisory Committe Report on Gulf War Illness and health of Gulf War Veterans
Smoking gun on how the IOM Panel ignored the findings of the RAC with regards to an infectious component to CMI and the outdated methodology of treatment protocols!
Infectious agents in multisymptom illnesses. Infectious agents have long been thought to play a role
in either triggering or perpetuating the symptoms of some patients with CFS and FM. Elevated rates of
fibromyalgia have been reported among patients infected with human immunodeficiency virus, hepatitis
C, and Lyme borreliosis.198,201,348 Prospective studies have also demonstrated that a subset of patients
develop CFS following different types of acute viral infection.209,796,875,1718,1776,1777,1787 Although findings
have been mixed, some studies have identified elevated viral titers in CFS and FM patients who have
been ill for prolonged periods—most prominently human herpes viruses and enteroviruses—suggesting a
possible role for reactivation of latent viruses in multisymptom conditions.7,186,243,360,471,493,822,1100,1499,1797
An association between mycoplasma infection and chronic multisymptom illness has been suggested for
both veteran and nonveteran populations.402,1118 Standard serological evaluations have not detected
evidence of mycoplasma infection in either Gulf War illness patients525,923 or civilians with CFS.829
However, studies using specialized polymerase chain reaction (PCR) methods have detected excess rates
of mycoplasma infection in both symptomatic Gulf War veterans355,1732 and in civilians with CFS and
FM.1095,1114,1123,1731,1732
Genetic parameters. A number of studies have indicated that multisymptom illnesses—both in the
general population and in Gulf War veterans—occur at higher rates among individuals with specific
genetic vulnerabilities or predispositions. Fibromyalgia and CFS have been reported to aggregate in
families64,199,1750 with CFS occurring at particularly elevated rates in identical twins
page 294
The second set of practice guidelines provides information on evaluation and management of veterans
with chronic unexplained illness, specifically symptoms of chronic pain and fatigue.1656 Information
provided on recommended treatments is based on the limited number of clinical trials published by 2001
that evaluated therapies for fibromyalgia and chronic fatigue syndrome. Information on other potentially
useful treatments is also provided, based on more preliminary research findings and the clinical
experience of panel members. The guidelines emphasize the use of cognitive behavioral therapy (CBT),
graded exercise, and antidepressant medications. Although exercise and CBT have been shown to
provide improvements for fibromyalgia and chronic fatigue syndrome patients, studies have found them
to be less helpful for ill Gulf War veterans.226,354,406 The clinical practice guidelines are also seriously
outdated in terms of the many studies of treatments for multisymptom conditions published since 2001,
particularly treatments for fibromyalgia.
page 215
https://www.va.gov/RAC-GWVI/docs/Co...andHealthofGWVeterans_RAC-GWVIReport_2008.pdf
Eco
I don't know if you had a chance to slog through the Research Advisory Committe Report on Gulf War Illness and health of Gulf War Veterans
Smoking gun on how the IOM Panel ignored the findings of the RAC with regards to an infectious component to CMI and the outdated methodology of treatment protocols!
Infectious agents in multisymptom illnesses. Infectious agents have long been thought to play a role
in either triggering or perpetuating the symptoms of some patients with CFS and FM. Elevated rates of
fibromyalgia have been reported among patients infected with human immunodeficiency virus, hepatitis
C, and Lyme borreliosis.198,201,348 Prospective studies have also demonstrated that a subset of patients
develop CFS following different types of acute viral infection.209,796,875,1718,1776,1777,1787 Although findings
have been mixed, some studies have identified elevated viral titers in CFS and FM patients who have
been ill for prolonged periods—most prominently human herpes viruses and enteroviruses—suggesting a
possible role for reactivation of latent viruses in multisymptom conditions.7,186,243,360,471,493,822,1100,1499,1797
An association between mycoplasma infection and chronic multisymptom illness has been suggested for
both veteran and nonveteran populations.402,1118 Standard serological evaluations have not detected
evidence of mycoplasma infection in either Gulf War illness patients525,923 or civilians with CFS.829
However, studies using specialized polymerase chain reaction (PCR) methods have detected excess rates
of mycoplasma infection in both symptomatic Gulf War veterans355,1732 and in civilians with CFS and
FM.1095,1114,1123,1731,1732
Genetic parameters. A number of studies have indicated that multisymptom illnesses—both in the
general population and in Gulf War veterans—occur at higher rates among individuals with specific
genetic vulnerabilities or predispositions. Fibromyalgia and CFS have been reported to aggregate in
families64,199,1750 with CFS occurring at particularly elevated rates in identical twins
page 294
The second set of practice guidelines provides information on evaluation and management of veterans
with chronic unexplained illness, specifically symptoms of chronic pain and fatigue.1656 Information
provided on recommended treatments is based on the limited number of clinical trials published by 2001
that evaluated therapies for fibromyalgia and chronic fatigue syndrome. Information on other potentially
useful treatments is also provided, based on more preliminary research findings and the clinical
experience of panel members. The guidelines emphasize the use of cognitive behavioral therapy (CBT),
graded exercise, and antidepressant medications. Although exercise and CBT have been shown to
provide improvements for fibromyalgia and chronic fatigue syndrome patients, studies have found them
to be less helpful for ill Gulf War veterans.226,354,406 The clinical practice guidelines are also seriously
outdated in terms of the many studies of treatments for multisymptom conditions published since 2001,
particularly treatments for fibromyalgia.
page 215
https://www.va.gov/RAC-GWVI/docs/Co...andHealthofGWVeterans_RAC-GWVIReport_2008.pdf
Eco
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