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Investigator bias and the PACE trial by Steve Lubet in Journal of Health Psychology

Discussion in 'General ME/CFS News' started by Yogi, Mar 8, 2017.

  1. Yogi

    Yogi Senior Member

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    Investigator bias and the PACE trial by Steve Lubet in Journal of Health Psychology
    http://journals.sagepub.com/doi/full/10.1177/1359105317697324

    Abstract
    The PACE investigators reject Geraghty’s suggestion that the cognitive behavior therapy/graded exercise therapy trial could have been better left to researchers with no stake in the theories under study. The potential sources and standards for determining researcher bias are considered, concluding that the PACE investigators “impartiality might reasonably be questioned.”

    http://me-pedia.org/wiki/Steven_Lubet
     
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  2. Tom Kindlon

    Tom Kindlon Senior Member

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    Lubet 2017.png

     
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  3. Tom Kindlon

    Tom Kindlon Senior Member

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    She has now added that this was Michael Sharpe:
    https://www.facebook.com/TomKindlon...d=786892678125526&comment_tracking={"tn":"R"}
     
    Last edited: Mar 8, 2017
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  4. Chrisb

    Chrisb Senior Member

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    He couldn't even get that right. Reputation perhaps.
     
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  5. alex3619

    alex3619 Senior Member

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    Logan, Queensland, Australia
    [Satire]

    "Oh, look" said the boy. "The Emperor has no clothes." He started giggling.

    The bystanders at first averted their gaze, and refused to say anything, then they all started pointing. Some started giggling too.

    The Emperor called for his guards. "Heads must roll, this is a plot against the Empire!"

    He was right, but the plot was in his court, not in public.
     
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  6. Barry53

    Barry53 Senior Member

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    I think in a way he probably will be proved right - his career hopefully does depend on it!
     
    Last edited: Mar 8, 2017
  7. Tom Kindlon

    Tom Kindlon Senior Member

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    C6bQ9NJWcAMibM7.jpg

     
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  8. Barry53

    Barry53 Senior Member

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    Steven Lubet looks to be a bit of a legal eagle, and well placed to draw the conclusions he has.

    Only one comment I would split hairs on:
    I think it warrants the corollary that they nonetheless wanted the best for themselves more.
     
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  9. Tom Kindlon

    Tom Kindlon Senior Member

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    She has now added that this was Michael Sharpe:
    https://www.facebook.com/TomKindlon...d=786892678125526&comment_tracking={"tn":"R"}
     
  10. Barry53

    Barry53 Senior Member

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    A Freudian slip it would seem.
     
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  11. Tom Kindlon

    Tom Kindlon Senior Member

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    Somebody reminded me of the following quote today which they suggested would have been good for this piece:

    Sean B M Kirby quoted it in his letter on the PACE trial:
    http://www.thelancet.com/journals/lanpsy/article/PIIS2215-0366(15)00110-8/fulltext
     
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  12. Barry53

    Barry53 Senior Member

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    It is why in engineering you have independent testers, often part of the QA (quality assurance) department, who have independent veto if necessary. Designers are still responsible for doing their own testing, but they absolutely do not have the last word on whether their work fulfils requirements to the necessary quality. I find it somewhat mind boggling that in something so crucial as medical research, the complete opposite seems the norm.
     
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  13. Yogi

    Yogi Senior Member

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    Hold on to your hats and everything else!

    The PACE trial is about to come in for a lot of turbulence.

    Many many thanks to @Keith Geraghty for all his hard work and everyone at Journal of Health Psychology

    10 + special commentaries



    This is the editor of the journal. Retweet if you have twitter to thank him - you vexatious harassing anti-science militants.

     
    Last edited: Mar 9, 2017
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  14. Snow Leopard

    Snow Leopard Hibernating

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    Wow, this level of debate around a trial (with the level of voices of patients being heard) is certainly unprecedented!
     
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  15. Chrisb

    Chrisb Senior Member

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    We can shortly expect to hear that this comment was taken out of context, (EDIT) and that it was, in any event, an obscure, unrecognised, literary allusion.
     
    Last edited: Mar 9, 2017
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  16. Yogi

    Yogi Senior Member

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    Great article and nice to see the legal side of things. Big thanks to Prof Steven Lubet for writing this publication. I would agree that that part of the conclusion is not right. I am unsure as a lawyer if he was just being very charitable to the PACE team.

    The article also stated "There are no comparably strict rules of recusal for clinical trials, nor could there be."

    Agreed in the context of pharmaceutical and medical device company conflicts of interest. However having insurance/DWP conflicts of interests throughout their careers is highly unusual (if not unprecedented) and diametrically opposed to the interests of patients unlike pharma examples.

    Corrected:
    "The PACE investigators state that they have “always wanted the best” for their insurance paymasters, of which I have no doubt at all"

    See:

    http://www.virology.ws/2015/11/17/t...surance-companies-not-related-to-pace-really/

    http://www.centreforwelfarereform.org/library/type/pdfs/in-the-expectation-of-recovery.html

    http://www.margaretwilliams.me/2013/role-of-science-media-centre-and-insurance-industry.pdf

    Good article overall!
     
    Last edited: Mar 9, 2017
  17. A.B.

    A.B. Senior Member

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    More like: the one time they were honest.
     
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  18. Solstice

    Solstice Senior Member

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    So am I correct to assume this is a massive blow not only for PACE, but for the entire model and it's authors?
     
  19. lilpink

    lilpink Senior Member

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    And certainly nothing they can use against 'us' at their upcoming SAS love-in. Not a hint of vexatiousness in sight.
     
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  20. Barry53

    Barry53 Senior Member

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    Just a bit of humour no doubt :rolleyes:. But such is the way with Freudian slips - the truth outs when not intending to.
     
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