Fair enough. I'm clutching at straws here but is there a possibility of latent autoimmune diabetes of adults (LADA) being misdiagnosed as type II diabetes? (noting that the CDC seem to think there's a high prevalence of metabolic syndrome in ME/CFS). Good old Wiki : Epidemiological studies do appear to link obesity with dementia but that's another thing altogether (?) : http://www.nia.nih.gov/alzheimers/features/big-belly-bad-brain-examining-body-fats-ties-dementia Sorry, been clearing out my potting shed today and rather lost my train of thought but I don't think I was suggesting that leptin levels trigger autoimmune disease but may contribute to sustaining it or to disease activity.