Edwards said :: I had not seen the Tan paper before. The question is why it was never followed up. Presumably it did not prove repeatable? If its one thing I know about CFS research is that so many interesting papers have been produced , but no-one follows them up. The reasons are various - mainly funding. It has always saddened me to see this. So please don't presume anything Prof Edwards. Maybe email Tan yourself to find out - that is the only sure fire way of finding things out in a field like this. The reduced blood volume work of Bell & Streeton was stunning, but it too was never followed up (Streeton died and Bell retired) . Each CFS research group are chewing away at their own part of this elephant, then if funds dry up no one seems to ever pick up the loose ends. Its just the way its been I'm afraid.