I'm rather encouraged by the CSF results as serum cytokines seem to be all over the place at the best of times. The elevated presence of (generally) anti-inflammatory IL-10 and 1L-13 seem somewhat at odds with pro-inflammatory IL-1b, IL-17 and TNF-a (I'll park IL-5 for the meantime) but ying and yang - for every action there's a reaction etc applies. IL-13 is elevated in parallel with IL-1b and TNF-a in rat models of Alzheimer's for example. This to me signifies neuroinflammation which is implicated in a wide range of mood and neurodenegerative disorders which may or may not be accompanied by gross tissue damage. Perhaps we need to define what constitutes 'inflammation'?