I was wondering if the autonomic system is misfunctioning by having messages blocked with an antibody then what type of effect would this lead to. Generally control systems tend to be complex dynamic systems with all sorts of feedback loops that determine how the system responds to both internal and external stimuli. Hence exercise or light might lead to messages that are mis-processes leading to a bad response but this in turn may lead to additional signals (from internal measures) making things worse. Hence the stimuli might cause a small immediate effect that gradually leads to cascade of bad control messages hence a crash. I was thinking it could be a bit like the economy going into recession where the initial build up of bad debt little immediate effect with consequential shock comming sometime later. The problem is dynamic systems with multiple feedback loops can be hard to predict, hence the need for modelling.