I understand your concerns Kati, but fortunately there is no need to worry here. The protocol Drs F,M and K use is the one I devised for my patients in 1999 and which the drug company subsequently took on as standard. The two week gap is actually an artefact of the way I was treating patients then and as far as we know can be one week. Oncologists are more prone to use the metre square rule for technical reasons relating to their cancer work. The topic came up because of the question of cost price (without profit) to a public healthcare system like NHS. It is interesting to know that the charge for infusion may be less than £1000 because I think the charging within the NHS 'internal market' may be a little creative. On the other hand the cost of $6000 for 1gm in the US would be a 100% mark up and that might be used to cover the overheads that otherwise would need to be covered by infusion fees. What is of interest here is the reasonable cost in the context of trials or compassionate use where profit is not factored in - i.e. for the immediate future. It is good to note that Genentech have been helping with drug costs but Genentech only hold the franchise for North America.