1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
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Invest in ME gut research fundraising target £100,000

Discussion in 'Fundraising' started by Kate_UK, Jun 18, 2014.

  1. Kate_UK

    Kate_UK Senior Member

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    Invest in ME (IIME) has set a new goal of £100,000 to fund future phases of the world-leading research on the gut microbiome in ME.
    Ways to donate: http://ldifme.org/donate/#IiME-BRF
    http://investinme.org/LDR newslet 1312-01.htm

    At IIMEC9 in May 2014: "Prof Simon Carding (Norwich, East Anglia) looked at the role for leaky gut and intestinal microbiota in the pathophysiology of ME. There has been an explosion of interest in the last 2 years. The gut is 9 metres long and has the largest collection of neural cells in the body. It could be described as our "second brain". It is also the largest immune system in the body with a huge area of surface villae. There are multi-layers of protection. The microbiota form a protective barrier. There are 100trillion microbes in the gut ranging from bacteria to fungi to viruses. So 99% of our DNA is microbial in origin. The microbiome refers to the genes. The microbiota weigh 1 kg and have a volume of 1L. There are between 300 and 1000 species. Food is the fuel for the bacteria and 1.4L of gas is produced daily. 60% of the stool is bacteria. The food and who we are shapes our microbiota. It is strongly influenced by species and region. The microbiota originate from our mothers and there are changes with age. They are there for protective function, structural function and metabolic function. In fact the intestine is a "bioreactor", and the microbiota are essential to providing our daily needs.
    The absence of microbiota compromises our health. "Germ free" animals have various defects as a result - such as a poor immune system and susceptibility to infection. Gut microbes however can cause disease in humans: e.g. H Pylori, clostridiae and enterococci.
    There is a microbiota gut/ brain axis - there is increasing evidence that the bacteria are a source of effects on brain function and disease. Stress also impacts on the microbes in the gut. The normal gut microbiota modulate brain development and behaviour. He asked the question "Is there a role involving the microbiota in ME?". There may be alterations in the intestinal barrier, leading to "leaky gut", malabsorption and inflammation. There are many possible causes of the so called leaky gut: drugs, infection, stress, antibodies, diet, neurotransmitters, cytokines, enzymes etc. Bacteria can breach a leaky barrier. There are many disease associations. In ME, IBS is common. This may be associated with auto-immune responses. Probiotics may have a potential role."

    https://www.facebook.com/ldifme?sk=wall
    maryb likes this.
  2. Min

    Min Senior Member

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    This tiny, volunteer run charity does the most wonderful work, and refuses to have anything to do with the Wessely school of psychiatry. I hope we can raise this amount for them as soon as possible.

    On way is for those of us in the UK to go through Easyfundraising everytime we buy anything online and Invest in ME will receive a small amount from each purchase:


    http://www.easyfundraising.org.uk/causes/investinme/
    justy likes this.
  3. Kate_UK

    Kate_UK Senior Member

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    Min and Sasha like this.
  4. Sasha

    Sasha Fine, thank you

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    @Kate_UK - thanks for posting this.

    Are there any details about the study? Is this for a specific study or is it an open-ended pot?
  5. Kate_UK

    Kate_UK Senior Member

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  6. Sasha

    Sasha Fine, thank you

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    So this is to continue funding of the project that had £100k raised for it initially? I can't see on the FAQs whether a further £100k will fully fund it.

    Is the study design on that page, or a total cost? I had a good look but maybe I've overlooked something.

    Thanks!
  7. Kate_UK

    Kate_UK Senior Member

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    I don't know any more, sorry. It says it is for the next phase.
    Sasha likes this.
  8. Sasha

    Sasha Fine, thank you

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    Thanks, @Kate_UK - hopefully IiME will put some info up soon. I think clear info encourages donations. If the study is already underway there should be a protocol and it would be a very quick job for one of the researchers to produce a short summary protocol for laypersons for fundraising purposes, as well as to explain what sort of financial goal this is.

    Looking forward to hearing more, at some point.
  9. ggingues

    ggingues $10 gift code at iHerb GAS343 of $40

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    Concord, NH
    Just breaking this up to make it easier to read.

    GG
    Sasha likes this.

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