So many symptoms I have are very contradicting and one of them is anger management. First of all, I have many defects in MAO SNP's and the combination of those defects make me inefficient at breaking down neurotransmitters. There are a lot of contradicting information on MAO defects. Some people say MAO defects contribute to inefficient breaking down of serotonin only. Some say it affects breaking down of catecholamines (epinephrine/norepinephrine/dopamine) negatively. Others say it slows down only serotonin and dopamine breakdown. Because of this, I am hesitant to make any definitive statements about MAO defect, but one thing I have realized from my experience is that I have lots of trouble with breaking down excess neurotransmitters in general. For all my life, I have been an introvert, restoring energy by having my own time rather than socializing in a group of people. This is quite different from what people often say about MAO genes, aggressive warrior genes. Here's a kicker. Even though I have been an introvert all my life, I've had problem with anger burst from time to time. Small irritants or stimulants bother me quite easily, whether it be noise, smell, people's behavior, caffeine, or even weather. Fortunately, I am able to cope in most situations and hold onto my emotion. In rare occasions, the level of irritation goes beyond the threshold, caused by either one big event or a buildup of small events, and that is when my anger bursts. Instead of walking away from a situation or resolving it logically, I start yelling, which is the last thing you would want to see from me. I have a resounding deep voice naturally, so it is quite a scene to watch when I am yelling. There are some supplements that make this issue worse. For instance, high dosage of L-glutamine (8~15 g) made me extremely irritable. High protein and meat consumptions also do not help very much. On the other hand, magnesium, niacin (no effect from niacinamide), and melatonin make me tolerate irritants better. However, these supplements have too much calming effect almost to the point where I can barely get excited, happy, or aroused. I am still trying to find a workaround for this, but have not been successful yet. Any insight on this would be greatly appreciated. There is no doubt that defects in MAO genes are contributing to this sudden burst of anger, but the mechanism behind this phenomenon remains a mystery. I wanted to see if there are members on this forum who have similar issues. Is there anything that we can do to resolve this permanently? What is really going on? How do you wash away your agitation? Did any supplements help greatly? Please share your experience!