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intrinsi b12

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by forbius, Feb 27, 2012.

  1. forbius

    forbius

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    I'm baffled that this hasn't come to my attention until now but I'm guessing there is a reason. I've found an "intrinsi b12" product that includes intrinsic factor as one of its ingredients. As a lot of you will know, an easily-exhausted amount of IF produced in the gut is what limits the amount of B12 that can be absorbed through oral supplementation. I'm assuming that there is a reason that nobody has tried or thought to supplement IF directly? Until now I just assumed it wasn't something that you could even supplement.
  2. brenda

    brenda Senior Member

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    Hi forbius

    If you take the B12 sublingually there is no problem with absorbtion so long as you take them as advised by Freddd. They go straight into the blood.
  3. forbius

    forbius

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    That's not really true, only a small percentage of the b12 actually makes it into the bloodstream that way. It is, however, better than oral supplementation. This doesn't really address the question I had.
  4. adreno

    adreno 3% neanderthal

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    Tundras of Europa
    I think it does address your question. When taken sublingually, we don't have to worry about intrinsic factor.
  5. Freddd

    Freddd Senior Member

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    Hi Forbius,

    Sublingual mb12 by Jarrow, which has had extensive testing, can be absorbed at a reliable 25% rate. That means that of a 5mg nominal dose 1250mcg can be absorbed in 2 hours. IF, when used to absorb b12 in the digestive system assures that 5-20mcg of b12 gets absorbed. I don't know the effectiveness of oral IF and how much b12 is absorbed with it but the whole transport system appears to be keyed in to that natural amount that is absorbed via IF. So taking an oral b12 one get about 100% abosrbtion up to avout 5mcg, then about 70% absorbtion fot the next 5mcg absorbed, about 50% absorbed of the next 10mcg and falling off to 1% beyond 100mcg, with 10-15mcg of the first 100mcg absorbed. The IF absorbed b12 is transported in the blood by HTC2. The sublingual appears to be dispersed by diffusion.
  6. forbius

    forbius

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    I use Swanson Ultra methylcobalamin, mainly due to the price (8 for 5mgx60, of which I bought 6 bottles a few months ago). Dropped it for a bit recently after experiencing tingling of the scalp and a metallic taste in my mouth when taking 25mg a day and an uneasy physical feeling (not sure of the cause), but will start it up again later. Have you tested this product?

    Ok. I'll see what the manufacturer has to say.
  7. Freddd

    Freddd Senior Member

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    Hi Forbius,

    I have not tested that product or had any reports of it's effectiveness made in comparison to Jarrow. The Jarrow is at least 100x more effective than some other brands of mb12 so there is all the difference in the world by brand and that had nothing to do with absorbtion rate. If you haven't tried the Jarrow and Enzymatic Therapy you have no idea. No other brands even came close. In all that time only 2 other brands have been reported on that lead me to believe that they may be at least 4 star. Much of the effectiveness of the sublingual b12 is bypassing all sorts of assumptions in the absorption and transport system by flooding the tissues with mb12 by diffusion.
  8. forbius

    forbius

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    I may try this product when I finish my current batch. I can only go by subjective response though. I recognise myself responding to my current methylcobalamin so I know that some of it is reaching me.

    I'm not sure what you meant by "bypassing assumptions".
  9. Freddd

    Freddd Senior Member

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    Hi forbius,

    By "bypassing assumptions" I mean all the things that have to work correctly for b12 to be transported by the active transport system. For oral dosing all these things are assumed to be working correctly and adequately. By being able to permeate the tissues and be available to all the needs it is more rapidly available than it it was forced through the 10mcg keyhole.

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