Intracellular magnesium defiency and vitamin B6 (and/or B2) deficiency in ME/CFS

Hi Rich

***Hi, AQ.

I don't think I was supplementing much of anything at the time of that first B6 test back in '06, certainly not mega dosages.

***O.K.

People on pyroluria groups tell me serum B6 readings are unreliable.

***They may mean that a serum B6 measurement tells you how much is in the serum, but not what is inside the cells, where the business takes place.

I didn't take any supplemental B6 between 2007 & 2011, bearing in mind Amy Yasko's cautions about B6 & the CBS SNPs, so no I was not taking any B6 at the time of that OAT in 2011, so that result is a puzzle.

***I'm assuming that you mean the high pyridoxic. I don't understand why it was high then, either, unless it means that your body was not able to use B6 very well, and was therefore dumping it.

Which raises the question, was I wasting B6 in the urine, and if so why?

***We must have two great minds!

KPU maybe?

***I think that's a possibility. Maybe low B2 is a possibility, also.

Calcium is in range on my recent CBCs.

***O.K. You probably don't have hyperparathyroidism then.

Alk phos is low in range. I've had my eye on it since hearing Klinghardt talk about it.. I think it has got lower over the years. A plasma amino acids test in 2010 was strongly suggestive of hypochloridia .. so that could be a clue to low zinc, I guess.

***Yes, low alkaline phosphatase can be caused by low zinc. And yes, low stomach acid can be caused by low zinc, too, though there are other possibilities, such as low glutathione, which you also appear to have had.

Thanks for taking the time to look at these.

Hard to know where to go next. I have been going around in circles for a while now.

Cheers
AQ

ETA: So how useful is it to supplement magnesium if it can't get into the cells because of some B6 bottleneck?

***I think that's a definite problem. Maybe raising B2 will help with the B6, which in turn will help with the magnesium. Alternatively, maybe it's HPU, and getting the Health Diagnostics test for that may be worth doing.

***Best regards,

***Rich

We do not have anything like your tests here rich but I follow your research closely - why I wonder was I losing/wasting potassium in urine early on (neon yellow no supps at the time). I heard adrenal problems.

Ok, Enid, I am a layperson, but someone was telling me that high potassium in the urine could be due to cell death.. apparently potassium is given off when the cells die. I had v. elevated apoptosis in tests I ran thru Acumen Labs in Devon (UK) back in the day. I'm sure you could google this to verify if it's accurate.. and there are probably other explanations also....

BTW, did you have the urine test done on the NHS?

And PPS, Genovations has an office in England .. so you can get some of these funky tests over there.. Just pricey & they all need to be repeated.... Hopefully, those of us this side of the Atlantic can advance the collective wisdom. I feel for you. The NHS has nothing to offer PWCS I know.

Hang in there Enid!

Thanks Rich. Yeah, more tests.. Yay!
Thankfully I am seeing results with B2 so that seems like a home run.
The 2 yrs I spent sucking down OSR & EDTA probably didn't help with low zinc either... Hindsight is great isn't it?

Thanks for your comments aquarius - luckily the neon urine has ceased and awful odour too. Working through all the good advice and much clearer thinking now. My Doc - usually too many bananas !

Yes. Damn those bananas. If I had known then what I know now about those darn things.......Ay!

Huh? I must have missed something; what's wrong with bananas?

Sarcasm.. enid's doc thinks some of her issues may be due to bananas.

I found a study about regulation of magnesium with b6, b12, and folate in relation to homocysteine.
Could this study have any relation to Rich's original post?
http://www.ncbi.nlm.nih.gov/pubmed/10553943