Hi! Not sure if this topic is already covered? Until I was about 28 (I am now 37) I was able to tolerate antidepressants for sleep or other sleeping pills like Diphenhydraminchloride (antihistamine which makes very tired). I occassionally took tricyclic antidepressants for sleep (even if I did not suffer from chronic insomnia in these times, it was more about stress). When I developped severe insomnia a few years ago I tried some of these antidepressants again (Remeron, Amitryptillin, Trimipramin...) and noticed that I feel very sick on it and have severe side effects even if the dose I took was so much smaller than usual! The normal dose of remeron is from 15 to 30 mg, Even 3,5 mg knocked me out and I felt terribly ill for days until I decided to stop this medication. Same effect with other medications (except Ibuprofen) and alcohol. I don't tolerate alcohol any more. Not tolerating antidepressants is really bad as my insomnia is so severe. I don't suffer from classic ME/CFS (I really don't know what I have, I was not diagnosed), but I am sooo senstitive to everything (heat, smells, noise, medication) and I used to tolerate this when I felt better many years ago. Does this sound familiar to you? Or do you tolerate antidepressants?