I already tried out IF (8/16) a couple of times but not strictly. Since it's meant to promote healing and regeneration of the body, I'm wondering if CFS/ME sufferers could benefit from it if done long term? The few times I tried it out I was completely fine. No worsening of any symptoms. But I have to mention that I was at a good state at that time. I'm debating if I should try it out longterm and see if my brain fog gets better. I found a pretty good article on: https://www.psychologytoday.com/blo...ittent-fasting-weight-loss-and-other-benefits Neurological: Calorie restriction increases the transcription of genes coding proteins involved in neuroplasticity and neuron survival. In rats and mice on an alternate-day fasting regimen, proteins that function to prevent protein damage in neurons are elevated. Calorie restriction, in general, up-regulates autophagy (which enhances removal of damaged proteins in cells). Energy restriction of 30% below what subjects typically consumed improved glucose metabolism, suppressed oxidative damage and inflammation, and protected against cancer, heart disease, diabetes, and muscle wasting in a study of non-human primates. It also preserves volumes of brain structures involved in emotional control. In animal models of reduced calorie intake, outcomes from stroke and traumatic brain injury are improved. Animals with experimentally induced strokes recover function better on restricted diets. Alternate day fasting protects rats from cognitive impairment in Alzheimer models. Calorie restriction protects dopaminergic neurons in rodent Parkinson’s disease models. Fasting improves memory in human subjects who reduce their daily caloric intake by 30%. It's important to note that while many studies strongly suggest there very well could be multiple benefits to our brains from IF, no definitive study has been done in humans that proves IF has a significant impact on the risk of getting a neurologic disease or effect on reducing the impact of a neurologic disease. From this one could suggest IF being super beneficial to cfs patients, but you never know... Has anyone made good/bad experiences with IF? Let me know!