Invest in ME Conference 12: First Class in Every Way
OverTheHills wraps up our series of articles on this year's 12th Invest in ME International Conference (IIMEC12) in London with some reflections on her experience as a patient attending the conference for the first time.
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Interleukin 2, 4, 5 are high, what does it mean?

Discussion in 'Diagnostic Guidelines and Laboratory Testing' started by TiredSam, Sep 30, 2016.

  1. TiredSam

    TiredSam The wise nematode hibernates

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    Charite005.jpg

    Above my results from the Charite in Berlin, showing my values above the normal range. These values were not listed or discussed in the "abnormal values" section of my report, but they look quite high to me. I'd be very grateful if any of you extremely clever types could tell me what this means, and if you could phrase your answer as if you were addressing a 5-year-old child that would be great :).
     
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  2. Valentijn

    Valentijn Senior Member

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  3. halcyon

    halcyon Senior Member

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    I believe those are all th2 cytokines, which are known to be elevated in ME patients.
     
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  4. Valentijn

    Valentijn Senior Member

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    IL4 and IL5 are part of Th2, but IL2 is part of Th1.
     
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  5. TiredSam

    TiredSam The wise nematode hibernates

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  6. Valentijn

    Valentijn Senior Member

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    It looks like IL8, IL10, IFNy and TNFA were tested, but presumably normal.

    If IL4 and IL5 are effected, IL10 is usually along for the ride. So that would possibly rule out the pathways for intestinal IgA production, T-cell signaling, and autoimmune thyroid disease.

    The remaining pathway where those results could make sense is the Inflammatory Bowel Disease, with those cytokines being listed in the "Th1 lymphocyte" box. No idea if that's at all in line with your symptoms though :p https://en.wikipedia.org/wiki/Inflammatory_bowel_disease#Signs_and_symptoms
     
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  7. justy

    justy Donate Advocate Demonstrate

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    If I were addressing a 5 year old child then perhaps - 'there are some naughty 'things' inside you that are making you feel ill all over'.

    Does that help ;)
     
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  8. worldbackwards

    worldbackwards A unique snowflake

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    Or if you were a middle aged man with ME: there's nothing wrong with you, stop asking questions and pull yourself together.:smug:
     
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  9. TiredSam

    TiredSam The wise nematode hibernates

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    IL8 is 88.4 (should be < 150)
    IL 10 is 66 (should be 25-364)
    Interferon gamma is 1016 (should be 265-6781)
    TNFA 4hLPS is 1334 (should be 300-2000)
    TNFA (CBA) is 398 (should be 68-1976)

    I have no bowel problems thank you very much indeed.

    I am going to throw such a tantrum in a minute ...
     
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  10. Valentijn

    Valentijn Senior Member

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    :D

    It might be a similar or identical process triggered by something else. Oh, and I think the funny symbol means IL4 and IL5 are being indirectly inhibited by T-bet in the "Th1 Lymphocyte" block. Whereas IL2 is being indirectly activated by T-bet after a few steps.

    So, um, no idea! But you're very special :sluggish:

    The Jak-STAT pathway might be worth looking into. It's getting mentioned in a few places involving your elevated cytokines, but their detailed map for it isn't showing Jak-shit (hurhur) regarding those cytokines.
     
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  11. TiredSam

    TiredSam The wise nematode hibernates

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    Just writing part 10 of my blog and found this in my report:

    T-Cell function after 24h polyvalenter ConA-Stimulation: TNFa, lFNg, IL-2, IL-4, IL-5, IL-10 normal

    Don't know if that changes anything? Hopefully I'm still special :sluggish:
     
  12. J.G

    J.G

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    Interesting thread. I've been thinking about getting my cytokines tested too.

    My thoughts: if chronic, post 3yr ME is indeed characterised by widespread immune dysregulation (to borrow Hornig's cutoff point and remarks), then your cytokine patterns could be reflective of that. This dysregulation in ME might bear a specific cytokine signature or may present differently both across patients and over time. We don't really know yet.

    If semi-random dysregulation is the norm, it will be difficult to attribute specific symptoms to one particular cytokine or a small combination of them. It's the big picture that matters. So yeah, perhaps the fact that your cytokine patterns don't fit anywhere is itself the number 1 takeaway.
     
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  13. TiredSam

    TiredSam The wise nematode hibernates

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    Thanks, still interested in opinions of anyone who knows about this stuff :).

    In 3 months it'll be 3 years since onset.
     
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