You cannot guess that it is compound heterozygous
Well, just got back my result from official health care center that confirmed it for me. I asked my geneticist there and he also said that compound are more common than recombined variants. To develope recombined variants to be more common than the original compound variant is also almost impossible. The high number of compound variants is evidence of that the recombined version never started from one person. Which also would be a hell of an coincidence if it survived evolution, cause the chance for it to "disapear" (die out) is huge. Only when the population have been VERY common with both variant you will start to develope some cases of recombinations that spreads out in the popullation.
I feel you are pretty naive if you think MTHFR gene polymorphisms only comes down to homocysteine levels and cardiovascular issues. Homocysteine may not be the culprit at all with MTHFR. Just an marker for some lucky people if they found out early in life. And for those it doesnt show up for (hard enough), it does not say anything about the status inside every cell in theire body, where MTHFR genes are suppose to work at 100%. I like to see MTHFR as every cells engine. Everybody understands that an engine working at 30% will have issues all over its components. And if you charge that engine with something, everybody knows that the chance for it to halt is far more the case than if it provided 100%. This is what happens in a body with cells working at 30%. If you develope issues because of poor efficiency in every cell the 30% working MTHFR gene (and the holde cell) will struggle real hard. Without methylation we all know that death is near. No cell can work without it.
Noone should simplify the meaning and importance of the MTHFR gene. You may not like (have a feeling) SNPedia, but this link shows you how severe (from a readers side) only the 677 SNP has been researched to create problems. And you can read the 2300 PubMed research wich is mentioned inside to find more problems. Its not hard to see that researcher really are interested in these MTHFR SNP's and the significant amount of issues connected to them. And every day I find new research that is poping up. Something tells me the odds for them to get the "patogenic" status will come some day. Today the status for the MTHFR T677T is
** With Uncertain significance allele ** - http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?rs=1801133
http://www.snpedia.com/index.php/Rs1801133
I did not double check my 3HCenko report that reported me beeing ++ for MTHFR M581I. Focused on the red ++ instead of the CC. Sorry for that. Will take it with the report makers.
Have quit all grains and diary products. Vegetables and healthy food has by itself (because of severe symptoms) been daily diet for decades. Does not touch alcohole or rafined sugar. Nope, my symptoms did not vanish.
What about my 3. question? Is it normal to "rename" SNP names? And why do they do that, if its a fact. Has something been discovered in between? I find lots of research and stuf when searching the new names of 677 and 1298...