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Interesting CBS Variations

Discussion in 'Genetic Testing and SNPs' started by Valentijn, Jul 30, 2013.

  1. Valentijn

    Valentijn Activity Level: 3

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    That's right, C699T GG is the version which has a risk of higher homocysteine.

    But there are three different ways in which homocysteine is disposed of: via CBS, via BHMT, and via MTR/MTRR. So even if your CBS is a little slow, the others (which are the more useful ones as well) might be functioning well enough to handle any excesses.

    As far as getting things "working" and ending up with high homocysteine, it depends on what you're trying to do. If you want to slow down CBS, etc, then higher homocysteine might result.
     
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  2. roxie60

    roxie60 Senior Member

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    Interesting, I have the GG variant yet low homocystiene which is a good thing. I am just wondering since I do not know what is keeping the homocystiene low as I work on improving methylation cycle if that would then cause a new problem, mainly homocystiene rising? Catch 22.
     
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  3. Valentijn

    Valentijn Activity Level: 3

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    Good methylation should result in "normal" (low) levels of homocysteine. But slowing down CBS further probably wouldn't be helpful for methylation.
     
  4. Bluebell

    Bluebell Senior Member

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    Roxie60, I am not a medical person, but I cannot see how improving your methylation cycle and getting everything flowing well would cause you to have poorer health (such as a worse homocysteine level).

    Just like the VDR situation, I would say this isn't a big thing to worry about.
     
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  5. Bluebell

    Bluebell Senior Member

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    V, those rs numbers are not in my 23andme data. They look a little longer than normal - do they really have 9 digits?

    None of my MTHFR SNP rs numbers start with 2676, nor end with 887 or 886.
     
  6. Valentijn

    Valentijn Activity Level: 3

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    Ah, those have "i" numbers. i5003529 and i5003530 respectively.
     
  7. Bluebell

    Bluebell Senior Member

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    Thanks for checking. I'm AA and TT respectively, so neither is the risky one.
     

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