Many PWME:s who have effect from immune modulators like antivirals, LDN and doxycycline seem to react slowly, but get better over time. It seems it can take six months or more before they start to get better but then they can feel better for many years. For me it's the other way around: The effect is instant but brief. I have effect within 24 hours. LDN and doxycycline does the same thing: The day after taking the first dose I get more energy and then comes the worsening of my psoriasis. After some time, between a week and a month, the energy effect goes away (and my PSO goes back to normal) and I have to increase the dose to keep the effect. If I stop doxy completely for some time (months) I again get energy from low doses. But it only lasts for so long. Recently I've started taking a very low dose of Famvir, 125 mg/day. I didn’t expect any reaction from such a low dose but I just realized that it is worsening my psoriasis and, I think, gives me swollen lymph nodes in the neck. I usually feel pain in my armpits but this neck thing is kind of new. It's possible that I have a little bit more energy too, it's hard to say what's what since I take other medications too. Of course I can't tell if it will be the same (neither LDN or doxy ever gave me anything but energy and PSO -- the swollen lymph nodes is new) but I guess I'll find out. If nothing else it will be another thing to alternate between to try to stay above my basic ME level which is a real horror (completely bed bound, communicating with notes). Anyone who recognizes this? I wonder if it's the fact that I'm pretty ill and that the thing that is wrong with my immune system has gotten "strong" enough to deal with any treatment I try. My ME beast (whatever it is ) gets hit instantly but fights back -- adapts to the new modulator -- pretty quickly. It's kind of annoying since I can't seem to get long term benefit from anything I try.