http://www.endotext.org/adrenal/adrenal31/adrenalframe31.htm After reading this link and i will need to read it again, the part that most strikes a cord with myself and cfs is the role of inflammatory cytokines in causing insomnia. This is definately us with chronic infections etc and interleukin(IL)6 seems to be that cytokine thats elevated and causing the problem. ALso IL6 increases with sleep deprivation so it a viscious cycle of high IL6 from infections that causes sleep problems and the sleep problems further increase IL6. Now im trying to google info on ways to reduce IL6 with some sort of anti-inflammatory, which i think will have to be specific to IL6, not just the everyday anti-inflammatories we take for aches and pains. I do know cycloferon has anti-inflammatory effects against viruses but not sure if its specific to IL6. I have been off cycloferon since the end of january and about to go back on it soon so will monitor my sleep when im back on it and see if it makes a difference. So all you cfs insomniacs, if u can find any good links and info relating to the above, please post. cheers!!!