I could not see much on that website that amounted to anything much more than simply taking magnesium, and not particularly high doses of magnesium either. ME/CFS patients take higher doses. But if there is something I missed on the website, please do explain. I spent around 15 minutes reading various bits of the site. High dose magnesium is used in ME/CFS, either by injection of magnesium sulfate, or by transdermal magnesium cream that you apply to your skin from head to toe (the method I use). You can't take very high doses of magnesium orally, because at a certain dose level (for me around 500 mg), magnesium causes bowel flushing (diarrhea). The benefits of high dose magnesium in ME/CFS likely arise not just from its nutritional effect (both intracellular magnesium and intracellular potassium are low in ME/CFS), but also from the effects high doses of magnesium have on the NMDA receptors: high dose magnesium acts as a good NMDA receptor antagonist, which will tend to have a calming effect on the brain, as it counters the over-stimulatory effect that high levels of glutamate exert via the NMDA receptors.