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Inhibition of XMRV by a weapon of mass deamination

Discussion in 'XMRV Research and Replication Studies' started by sproggle, Apr 20, 2010.

  1. sproggle

    sproggle Jan

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    Teesside, England UK
    Inhibition of XMRV by a weapon of mass deamination by Vincent Racaniello on 20th April 2010

    Any science brains upto translating this article?

    http://www.virology.ws/2010/04/20/inhibition-of-xmrv-by-a-weapon-of-mass-deamination/?utm_source=feedburner&utm_medium=feed&utm_campaign=Feed:%20VirologyBlog%20%28virology%20blog%29"
     
  2. Gerwyn

    Gerwyn Guest

  3. natasa778

    natasa778 Senior Member

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    Very interesting thanks, I wonder if something like this - differences in Apobec gene/s, could be one of reasons some can carry XMRV (or HIV) and not develop disease.

    Here are several other papers:

    APOBEC3 inhibits mouse mammary tumour virus replication in vivo
    http://www.nature.com/nature/journal/v445/n7130/full/nature05540.html
    ... Genomes of all mammals encode apobec3 genes, which are thought to have a function in intrinsic cellular immunity to several viruses including HIV-1... However, the role of A3 in innate resistance to mouse retroviruses is not understood. Here we show that A3 functions during retroviral infection in vivo and provides partial protection to mice against infection with mouse mammary tumour virus (MMTV). Both mouse A3 and human A3G proteins interacted with the MMTV nucleocapsid in an RNA-dependent fashion and were packaged into virions. In addition, mouse A3-containing and human A3G-containing virions showed a marked decrease in titre. Last, A3-/- mice were more susceptible to MMTV infection, because virus spread was more rapid and extensive than in their wild-type littermates.

    APOBEC3 proteins mediate the clearance of foreign DNA from human cells http://www.nature.com/nsmb/journal/v17/n2/full/nsmb.1744.html


    Gerwyn or anyone, could Apobec (dys)function be in any way linked to abnormalities of Rnase L in CFS?
     
  4. natasa778

    natasa778 Senior Member

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    how can this be?? surely you must mean something else? http://en.wikipedia.org/wiki/Cytoplasm
     
  5. leaves

    leaves Senior Member

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    Heheh I was reading: inhibition of xmrv by a weapon of mass destruction.
    Might be effective though... :)
     
  6. CBS

    CBS Senior Member

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  7. Overstressed

    Overstressed Senior Member

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    Belgium
    If I can remember correctly, long term HIV non-progressors have high expressions of APOBEC proteins, that control retrovirus infection. And yes, I assume the same mechanism will control XMRV.

    OS.
     
  8. Gerwyn

    Gerwyn Guest

    It is a form of molecular hopscotch.The viruses literally jump from one organelle membrane to another by a system of pino and phagocytosis. They dont avoid the cytoplasm altogether but dont spend enough time there to invoke an immune response.I will and try to post the details when i feel a bit better
     

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