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Influenza vaccine in cfs/me

Discussion in 'Latest ME/CFS Research' started by heapsreal, Mar 26, 2014.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    Thought i would post this study again since its been a recent topic of late.

    http://research-hub.griffith.edu.au/display/n4b0a7815dbaac7c5e227950c438e0030

    ABSTRACT

    Immune dysfunction is a hallmark of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). The purpose of this pilot study was to identify the effects of influenza vaccination on immune function in patients with CFS/ME. We included 7 patients meeting the Centre for Disease Control and Prevention criteria (CDC 1994) for ME/CFS and 8 control subjects. Bloods were collected from all participants prior to vaccination with Influvac, a trivalent inactivated influenza vaccine (TIV), 14 and 28 days following vaccination. The immune parameters examined include Natural Killer (NK) phenotypes, NK cytotoxic activity, FOXP3 and Th1/Th2/Th17 related cytokines. Flow cytometric protocols were employed. There was no significant difference in NK phenotypes and Tregs numbers between CFS/ME patients and healthy controls. However, NK activity was significantly decreased at baseline and at 28 days, while at 14 days it significantly increased in the CFS/ME patients compared to the healthy controls. Th1 pro-inflammatory cytokines increased considerably in the CFS/ME patients at 28 days compared to the non-fatigued controls. Only one Th2 cytokine, IL-4, increased in the CFS/ME participants. FOXP3 expressing Tregs only increased significantly at day 28 post vaccination in the CFS/ME patients compared to the healthy controls. Self-rated wellbeing was lower for patients at day 28 while at baseline and day 14 no differences were observed. In this pilot study immunization with influenza vaccine is accompanied by a degree of immune dysregulation in CFS/ME patients compared with controls. While vaccination may protect CFS/ME patients against influenza, it has the ability to increase cytotoxic activity and pro-inflammatory reactions post vaccination. The role of Tregs in promoting a toxic effect at 28 days post-vaccination in our patient group cannot be ruled out. The benefits of influenza vaccine still likely outweigh the risks CFS/ME patients experience following vaccination.
    alex3619, Helen, Ruthie24 and 4 others like this.
  2. Grigor

    Grigor

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    Hmmmm so better not take an flu shot then??

    I actually had a major crash in november . Always wondered why. I was already bad in april but in November was rockbottom.
  3. SOC

    SOC Moderator and Senior Member

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    Not necessarily. The conclusion of the researchers was
    It's neither a condemnation of influenza vaccination for PWME, nor a whole-hearted endorsement.

    It appears we have more trouble with the flu vaccine than the average person, but not a serious enough reaction to suggest we should not take the flu vaccination (as a general rule). This study probably shows the simple reality of living with ME/CFS -- everything is tougher for us. In this case, we (in general) probably need the flu vaccine, BUT we'll have a more noticeable reaction to it than most people. This illness sucks.
    Last edited: Apr 1, 2014
    Ruthie24, Battery Muncher and barbc56 like this.
  4. Grigor

    Grigor

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    Lol ok. So that didn't give me any joy then ;-)

    Though I have never been as bad as I am now. So not sure if I should take it again.
  5. SOC

    SOC Moderator and Senior Member

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    That's one of the many problems for us -- do we take vaccines or not? Most of the top docs are saying you should take killed virus vaccines, but not live virus vaccines....BUT if you had a bad reaction to a particular vaccine in the past, you should consider if the vaccine is worth the reaction you had before you take it again. Lots of help, eh? :rolleyes:

    Lots of us get worse in Nov/Dec, so I wouldn't necessarily attribute that to the vaccine. It might be that, of course, but it might also be multiple exposures to colds, flu, and other winter bugs. Or something else entirely like reduction in vitamin D from less sunlight. Or who knows what? ME/CFS -- always a new adventure in misery.
    Battery Muncher likes this.
  6. Grigor

    Grigor

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    Lol. True. I've never been bad around that time. But right now. March is always tricky for me. Lots of crappy things happen here.
  7. Valentijn

    Valentijn Activity Level: 3

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    They'll never make a statement opposing vaccine use for pretty much anyone.

    The general take away from these sorts of studies is "Yeah, flu vaccines do some weird stuff to the immune system of ME patients. We don't know what's happening, or how long it lasts, but get vaccinated anyway!"
    NK17, Ruthie24, ukxmrv and 1 other person like this.
  8. Grigor

    Grigor

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    Hmm yeah weird stuff. I mean I had a relapse before I took the vaccine. But as I said the jackpot was in November. Wondered if that was related. We'll never know.
    manna likes this.
  9. Thomas

    Thomas

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    @Grigor I hear you man. My ME was triggered by a flu shot in November of 2011.
    manna likes this.
  10. Wayne

    Wayne Senior Member

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    Helen likes this.
  11. Ruthie24

    Ruthie24 Senior Member

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    Thanks Heaps for posting this. Know you did it awhile ago but was in a crash then so missed it.

    Personally every year I get the vaccine I have terrible upper respiratory problems so no more for me. My doc agrees.
    heapsreal and Wayne like this.
  12. Snow Leopard

    Snow Leopard Senior Member

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    In my opinion it is the live-attenuated vaccines that are risky and the risk is similar to getting the virus itself - the risk of inducing the immunological changes involved in maintaining or worsening ME symptoms.
    Helen and SOC like this.
  13. chipmunk1

    chipmunk1 Senior Member

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    live vaccines can be a problem for people with weakened immune systems

    http://www.cancer.org/treatment/tre...-people-with-cancer-vaccines-during-treatment

    http://www.nhs.uk/Conditions/vaccinations/Pages/bcg-tb-vaccine-questions-answers.aspx#immune

  14. Dr.Patient

    Dr.Patient There is no kinship like the one we share!

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    Hello, I am very interested in how your flu shot got you ME. If you don't mind, could you share the timeline...also, do you remember the type of flu shot that you got, thanks. Did you get a flu after the shot?
  15. Thomas

    Thomas

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    I don't remember which type it was. I got it on November 10th 2011 and felt weird right away. Then the acute flu or virus or reaction from the shot happened on November 20th 2011.
    Wayne likes this.
  16. SOC

    SOC Moderator and Senior Member

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    Do you know if you only got the killed flu virus vaccine? Sometimes they give the pneumovax at the same time which is known to cause a hypersensitivity rxn in some patients. It gave me a lot of trouble when the preservative-free, killed virus flu vaccine doesn't. Everybody is different, of course. :)
  17. Dr.Patient

    Dr.Patient There is no kinship like the one we share!

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    Thank you, it was an injection and not a nasal vaccine?
  18. Thomas

    Thomas

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    Pretty sure it was just the dead virus flu shot without any additional vaccines. And it was a shot, not the nasal vaccine. Were your ME's triggered by vaccines or did you have one within 20 days of onset?
  19. Dr.Patient

    Dr.Patient There is no kinship like the one we share!

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    Not by a vaccine, but by the flu itself, thanks
  20. SOC

    SOC Moderator and Senior Member

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    No, my ME was not triggered by a vaccine. I did have a significant setback when I had a flu shot (with preservatives) and the pneuomovax at the same time, but I was years into ME at that point. Since then I've had the killed virus preservative-free flu shot with no problem at all. Same with my daughter who also has ME. That doesn't mean everyone with ME can take the flu shot without consequences, of course. :)
    Sushi likes this.

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