Hello, I have been on B12 for almost 4 years, and it has saved my life, thanks Freddd and everyone who has shared their experiences! When I first tried Metafolin and adB12 with the protocol 4 years ago, they didn't seem to do anything for me, so I went off of them after a couple of months, staying on mB12 and other supplements, including LCF and SAM-e. When some kind soul put out the updated compilation of Freddd's protocol, I decided to have a go at it again, switching my mB12 from AOR to Country Life (an improvement), and adding in Metafolin (helpful this time), and adB12 (noticeable the first few days, then not). I am now at daily dosages of 15mg mB12, 8.5mg adB12, and 9.6mg Metafolin. I have been gradually increasing the Metafolin from when I started 2 weeks ago as I had an initial strong positive reaction to that, but left the mB12 and adB12 at their original dosages. I have experienced no terrible side effects to anything, and positive effects were most pronounced in the beginning. (The first 3 days - wow, amazing!) When I feel what may be hypokalemia, potassium seems to calm it down, and though I have had some tired, minor-crash periods (minor brain fog and nervous system/body tiredness are the most pronounced symptoms), there have been no major crashes like what people have described on here due to paradoxical folate deficiency or methyl-trap. My question is about increasing dosages. I've upped the folate pretty rapidly so far, with no negative effects, and wonder how I would know when I have increased it to an optimal dose. I'm not getting much new from the adB12 anymore, and less from the B12, so I guess I could increase those more too, though I tried a mega-dose of 50mg mB12 several years ago, and it didn't do much more than 15mg. I think I have read on other threads that it is wise to raise levels until symptoms decrease/level out, but I'm not experiencing major paradoxical/methyl-trap symptoms, so I'm not sure if that is a good gauge. Raise them until an increase no longer produces an improvement? I'm going to double the adB12 today so it is at a 1:1 ratio with mB12, but if I don't notice anything, I may drop it back down. I'd like to get the mB12/adB12/folate ratio down, and then I will tinker with raising LCF. Thanks in advance!