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Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder.

Discussion in 'Other Health News and Research' started by hixxy, Oct 25, 2016.

  1. hixxy

    hixxy Senior Member

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    Increasing Comorbidities Suggest that Atopic Dermatitis Is a Systemic Disorder.

    Brunner PM, Silverberg JI, Guttman-Yassky E, Paller AS, Kabashima K, Amagai M, Luger TA, Deleuran M, Werfel T, Eyerich K, Stingl G; Councilors of the International Eczema Council.

    Abstract


    Atopic dermatitis comorbidities extend well beyond the march to allergic conditions (food allergy, asthma, allergic rhinitis, allergic conjunctivitis, and eosinophilic esophagitis), suggesting both cutaneous and systemic immune activation. In reviewing atopic dermatitis comorbidities, Councilors of the International Eczema Council found a strong pattern of immune activation in peripheral blood and the propensity to both skin and systemic infections. Associations with cardiovascular, neuropsychiatric, and malignant diseases were increasingly reported, but confirmation of their link with atopic dermatitis requires longitudinal studies. Given the possibility of atopic dermatitis-related systemic immune activation, future investigations of new interventions should concurrently examine the impact on these comorbidities.

    Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

    http://www.jidonline.org/article/S0022-202X(16)32366-1/abstract
     
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