Hi Suzanne, I would like to make a couple of comments here. A rise from 1000mcg to 1250mcg, as sublingual I assume?, is unlikely to make a noticable differene in most people. To have a gangbusters change becasue of that is unlikely. When we were doing the testing, 5 hypersensitives, and I was also doing the symptoms histories and single dose trials, most people could not tell the dofference between the 5 star 1mg and 5mg. The same people had the same reactions to both. Intensity wise they were so close to identical that it didn't seem to make anu difference. Where the difference showed up was when somebody had reached equilibrium on 1mg, 1 5 mg would have some startup again, and then 10mg over 5, and 15 over 10. But as far as an absolute difference, it made no real difference. I settled on the 1mg Jarrow for the many trials because they were the least expensive 5 star mb12. There was no reduction in response or response rate. In studies, both 120mcg and 1500mcg doses were effective, but 1500mcg was somewhat faster. That might have everything to do with the tissue penetration issue. SO dropping back to 1000mcg is no problem but I don't think that it will solve the problem. I would also say that the dose of potassium is awfully high. It doesn't even seem in the same ball park as others are finding needed. I would be trying to damp down the system, to slow down fluctuations and keep it predictable. When my whole system has gotten hopelessly unbalanced, as yours seems at the moment. The strategy I've used, that has always worked for me, is to cut back to basics, ie basic vitamins, minerals, fats (lecitinin and omega3). In the basic minerals, cut back any calcium, magnesium, zinc that are in excess of bascis and bring down the potassium rto perhaps 600mg a day and work from there. Also getting rid entirely of all special purpose things from yeast based vitamins, special food supplements, whey, chorella, glutatmine, chelating things etc. Sometimes in multi ingrediant pills, things kind of accumulate out of sight and out of control. I'm not singling out any specific things here but rather all sorts of things that may have gotten out of balance and those things unnessary for normal functioning and all those things that could conceivably be causing known or suspeted problems, or where it's unknown combinations havong unexpected effects. It's sort of like an ellimination diet. SIMPLIFY. Then rebuild carefully after the things have had a suitable washout time. The glutathione, if you are even taking it or not, can have effects for quite a while after quitting it as an example. Too much calcium, especially out of balance, can be a major problem. The minerals tend to clear quickly. Just dropping back the potassium to 600mg will keep you out of severe trouble happening fast and not be enough to thow things off. After things stabilize then examine what the remaining symptoms need. I would keep zinc no higher than 50mg at this time, get rid of the SAM-e, TMG, D-Ribose, mb12 at 1000 mcg, adb12 at 2500mcg each 3 days and mMetafolin at 800-1600mcg. This will allow these things to work well. Get rid of all folic acid and folinic acid for now until you know which way is up. If you are vegetarian, keep the l-carntine fumarate going as that is essential for healing in many people.