The Call for Opposition: Challenging the P2P and IOM Processes
In our second article on how to react to the publication of the draft P2P report, Gabby Klein provides her view of why she and a large group of advocates and patients are continuing their protest of the government’s ongoing control and manipulation of our disease via their processes...
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Inactive B12s unique situation/sam-e

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by GenDylan, Oct 28, 2013.

  1. GenDylan


    how would i know when/how much active b12 i am getting out of inactive b12 supplementation (cyano/hydroxy)

    this is necessary to know because, id like to take MethylFolate as well - and i dont want to be methyl-blocked due to a lack of active b12 being formulated from the inactive's.

    i do understand that Methyl B12 is "the best b12 to take" ,because its the byproduct of the inactive b12s/skips the conversion process.
    --but i am in a unique situation. - Sam/Sam-e is an allosteric inhibitor to MTHFR; i supplemented w/Methionine and raised my SAM levels; and now SAM is inhibiting my folates. --- so, id prefer to take an inactive b12 now,because inactive b12's use up SAM/e to get converted to Methyl B12 ; as opposed to methyl B12 just increasing SAM.

    so, if anyone has any light to shed on inactive b12s w/methylfolate supplementation, or inactive b12's relationship w/SAM-e...

    thanks yall.

    also @Freddd , if you have any knowledge on - how much SAM/e is produced w/b12 & methylfolate supplementation. if possible, id like raise my Folate/b12 levels much more than my SAM/e levels.
    im just trying to do anything i can to maximize my "folate/SAM ratio".
    so maybe supplementing as much 5MTHF as possible w/ as little B12 as possilbe w/o getting methylBlocked will reduce the SAM/e created ; as opposed to excessive b12 supplementation..

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