Review: 'Through the Shadowlands’ describes Julie Rehmeyer's ME/CFS Odyssey
I should note at the outset that this review is based on an audio version of the galleys and the epilogue from the finished work. Julie Rehmeyer sent me the final version as a PDF, but for some reason my text to voice software (Kurzweil) had issues with it. I understand that it is...
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Inactive B12s unique situation/sam-e

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by GenDylan, Oct 28, 2013.

  1. GenDylan


    how would i know when/how much active b12 i am getting out of inactive b12 supplementation (cyano/hydroxy)

    this is necessary to know because, id like to take MethylFolate as well - and i dont want to be methyl-blocked due to a lack of active b12 being formulated from the inactive's.

    i do understand that Methyl B12 is "the best b12 to take" ,because its the byproduct of the inactive b12s/skips the conversion process.
    --but i am in a unique situation. - Sam/Sam-e is an allosteric inhibitor to MTHFR; i supplemented w/Methionine and raised my SAM levels; and now SAM is inhibiting my folates. --- so, id prefer to take an inactive b12 now,because inactive b12's use up SAM/e to get converted to Methyl B12 ; as opposed to methyl B12 just increasing SAM.

    so, if anyone has any light to shed on inactive b12s w/methylfolate supplementation, or inactive b12's relationship w/SAM-e...

    thanks yall.

    also @Freddd , if you have any knowledge on - how much SAM/e is produced w/b12 & methylfolate supplementation. if possible, id like raise my Folate/b12 levels much more than my SAM/e levels.
    im just trying to do anything i can to maximize my "folate/SAM ratio".
    so maybe supplementing as much 5MTHF as possible w/ as little B12 as possilbe w/o getting methylBlocked will reduce the SAM/e created ; as opposed to excessive b12 supplementation..

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