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In vitro assembly of virus-like particles of a Gammaretrovirus (XMRV)

Discussion in 'XMRV Research and Replication Studies' started by Jemal, Nov 17, 2011.

  1. Jemal

    Jemal Senior Member

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    I have no idea what it means...

    http://jvi.asm.org/content/early/2011/11/09/JVI.05564-11.abstract?related-urls=yes&legid=jvi;JVI.05564-11v1
     
  2. Tony Mach

    Tony Mach Show me the evidence.

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    Upper Palatinate, Bavaria
    As far as I understand, they studied how the individual pieces of a XMRV virus ("structural proteins") fall together ("are assembled") to form virus-like particles (I guess either incomplete viruses or a intermediate step to a full virus but I could be wrong). They seem to have found differences in the assembly to other Gammaretroviruses whether these differences are big or subtle, I can't tell.

    If XMRV were a human pathogen, this could offer clues how to block this step in virus formation. As it stands, XMRV is not a human pathogen so this only helps further the understanding of viruses in general.
     
  3. Bob

    Bob

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    England (south coast)
    I'm not sure exactly what it means either. Like Tony said, it seems to be exploring the way that immature viral particles combine to form mature viruses. But I can't work out what the significance might be from reading only this abstract.
     
  4. Enid

    Enid Senior Member

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    Whatever it does mean, it is good to see advances in the understanding of viral behaviours going on. (I'm not a scientist though).
     

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