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Improving methylation may trigger EBV relapse

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by Dreambirdie, Jul 21, 2015.

  1. Dreambirdie

    Dreambirdie work in progress

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    This is definitely of concern to me.

    So it uses your methylation processes to replicate itself?
    So, just to explain it again, here’s what it does:

    • EBV must first establish a latent B cell infection in order to keep them alive long enough to produce new viral particles
    • EBV DNA is unmethylated upon infection, but becomes methylated over time by the host B cell
    • The BZLF1-encoded protein, Zta (a cousin to AP-1), induces the viral lytic cycle (this means part of the reproductive cycle), but it prefers binding sites that are methylated. So the lytic phase gets delayed until enough methylation has occurred.


    What do others think? @Dufresne @AndyPandy @caledonia @Critterina @ahmo

    http://ihateticks.me/2015/05/22/war...on-may-trigger-an-epstein-barr-virus-relapse/
     
  2. ahmo

    ahmo Senior Member

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    :eek:I can only report that my methylation has been*repaired* for about a year, with no evidence of EBV activation.
     
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  3. Dreambirdie

    Dreambirdie work in progress

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    That's reassuring to know.
     
  4. ahmo

    ahmo Senior Member

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    I don't know if this is relevant, I didn't add it to original post: my herpes has pretty much disappeared during this past year. Maybe not same profile/action as you've quoted for EBV.
     
  5. AndyPandy

    AndyPandy Making the most of it

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    I am new to methylation and don't know enough to comment on this.

    Best wishes, Andy
     
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  6. dannybex

    dannybex Senior Member

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    I'm a dufus when it comes to these things, but the author of the blog starts out with a factual error in her first sentence of the third paragraph when she says:

    "EBV is a retro-virus.."

    Uh, no. It's a virus.

    And it seems most of her references were in vitro cell-line studies.

    Lastly, I think we would've seen some sort of report of worsening EBV infections in the many folks doing various methylation protocols.

    Dufus Dan
     
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  7. Dreambirdie

    Dreambirdie work in progress

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    Good points, @dannybex

    thanks for your input.
     
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