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Implications of low LDH (lactate dehydrogenase) in ME?

Thinktank

Senior Member
Messages
1,640
Location
Europe
Since becoming ill i've tested low in LDH (lactate dehydrogenase), doctors always waived it as not important so i haven't given it much thought. Today i stumbled upon a page on healthline about LDH mentioning the following:

LDH deficiency affects how the body breaks down sugar for use as energy in cells, particularly muscle cells. It’s very rare for a person to have low LDH levels.

Two types of genetic mutations cause low LDH levels. People with the first type will experience fatigue and muscle pain, while those with the second type may have no symptoms at all.

From wikipedia:
LDH catalyzes the conversion of lactate to pyruvic acid and back, as it converts NAD+ to NADH and back. A dehydrogenase is an enzyme that transfers a hydride from one molecule to another.

A deficiency in LDH type A is also called glycogen storage disease XI.

To me it sounds like a deficiency in LDH will exacerbate ME, or may be misdiagnosed as ME.

More info:
https://www.mda.org/disease/metabolic-diseases-of-muscle/types/lactate-dehydrogenase-deficiency

Anyone else here with repetively low LDH?