1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
Ergonomics and ME/CFS: Have You Hurt Yourself Without Knowing It?
Having a chronic illness like ME/CFS can make it hard to avoid problems that come from bad ergonomics. Jody Smith has learned some lessons the hard way ...
Discuss the article on the Forums.

Immunobilan test?

Discussion in 'The Gut: De Meirleir & Maes; H2S; Leaky Gut' started by acer2000, Mar 14, 2012.

  1. acer2000

    acer2000 Senior Member

    Messages:
    577
    Likes:
    216
    Hey guys,

    I few months ago my Dr. did an ImmunoBilan test on me. Its basically a test that measures IGM and IGA immune response against several gut bacteria. The theory is, if you have these antibodies in your blood it means the bacteria have entered the bloodstream and your guy is leaky. Drs use antibiotics to beat them back and you are supposed to feel better. I believe KDM does this treatment.

    I am wondering, what is a "normal" value for this test? At first I had many elevated IGM and IGA values. I then took Rifaximin (an antibiotic) and now my test has no IGM values, but a few of my IGA ones persist. My doctor says thats "normal" and I don't need to be treated again. But I don't feel any better. I am wondering if anyone else who has done this treatment can comment on what constitutes finishing the treatment? Are lingering IGA antibodies "normal", or did your doctor treat until they were all gone? Did you end up feeling any better in the end?
  2. Waverunner

    Waverunner Senior Member

    Messages:
    995
    Likes:
    841
    I did this test several times. Had high IgM and IgA against certain bacteria. Got treated with antibiotics. Values dropped but they never were completely normal. Didn't feel much improvement from it. Probably plays a role in CFS but is not the cause.
  3. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,220
    Likes:
    4,524
    australia (brisbane)
    i Have had consistantly high iga immunoglobulins, borderline high igm and igg immunoglobulins. My doc just says that it shows your immune system is activated or irritated. I think iga immunoglob play a aprt of the health of mucous lining in the body ans this is where possiblr infections are??
  4. Athene

    Athene Never give up

    Messages:
    1,130
    Likes:
    150
    Italy
    It's a waste of money.

    I had this test and had the treatment, and I keep in touch with another KDM patient who also did it and had the treatment. We both found that the test results had no correlation with our gut or other symptoms. Following treatment, her results were much better, but she felt the same as before, and mine were worse, I had slightly better guts but felt drastically worse generally. It was throwing up totally random results.

    It is certainly not a reliable test for leaky gut.

    We both came to the conclusion that this test is not measuring anything that is useful to know, and the results cannot be translated into any form of useful therapy.
  5. Waverunner

    Waverunner Senior Member

    Messages:
    995
    Likes:
    841
    Thanks for clearing this up, Athene. Seems we all had the same experience.
  6. acer2000

    acer2000 Senior Member

    Messages:
    577
    Likes:
    216
    OK thanks for all the info. Is there another more accurate way to figure out what is causing my leaky gut? My standard parasite, c. diff, etc.. stuff always comes back negative. I avoid all the foods I'm allergic to. SIBO test negative. Still leaking according to the lactulose mannitol test.
  7. richvank

    richvank Senior Member

    Messages:
    2,717
    Likes:
    747
    Hi, acer.

    Have you run the methylation pathways panel? If you have a partial methylation cycle block, which this panel tests for, that will also mean that the folates in the cells are depleted. Folates are needed to make new DNA and RNA so that the cells can divide to make new cells. This is important for the lining of the gut, because the cells there have fairly short lifetimes and need to be replaced soon by new cells. If the process for making new cells is inhibited by folate depletion, I suspect that the lining of the gut will suffer. Another aspect of this is that glutathione will also be depleted if there is a methylation cycle partial block, and that is important for protecting the gut from oxidative stress and toxins.

    Best regards,

    Rich
  8. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,220
    Likes:
    4,524
    australia (brisbane)
    If immunoglobulins test low then someone should be a candidate for gammaglobulin therapy which can give the immune system a boost.

    cheers!!!
  9. Athene

    Athene Never give up

    Messages:
    1,130
    Likes:
    150
    Italy
    You could try taking these supplements:

    Glucosamine Hcl (Jarrow)
    N-Acetyl Glucosamine (Jarrow)

    I've been using them for about 6 months now. They restored my ability to make GLUT-5 and thus absorb fructose in a matter of weeks. I've been testing milk and gluten and NOT getting headaches from them any more, which makes me think they have done some major mending of the leakiness.
  10. Tony

    Tony Still working on it all..

    Messages:
    359
    Likes:
    40
    Melbourne, Australia
    Hi folks,

    With KDM it's only one part of the testing regime he uses. I doubt he would treat anyone on this test alone. Stool testing is also used. See here for an idea of these: http://www.redlabs.be/red-labs/our-tests/intestinal-dysfunction-assays.php

    Have you thought of doing a fructose breath test for malabsorption? It's pretty common in ME/CFS folk and if we 'fail' it wheat is a real culprit, amongst other things. Sorry if you're already past that part of testing. Just a thought...

    As for therapy I'm very happy with what KDM has done for me. I have an improved life thanks to the various a/b's treatment etc. I don't think it's helpful to throw the baby out with the bath water here...:)
  11. Athene

    Athene Never give up

    Messages:
    1,130
    Likes:
    150
    Italy
    G'day Tony!
    Glad to hear you're still doing well and improving!
    :)
  12. Tony

    Tony Still working on it all..

    Messages:
    359
    Likes:
    40
    Melbourne, Australia
    Ciao to my favourite Sicilian housewife/author/blogger/mum etc...:)

See more popular forum discussions.

Share This Page