Discussion in 'Other Health News and Research' started by natasa778, Mar 10, 2014.
Interesting that they mention nivolumab above, which works by blocking PD-1 - how intriguing!
Some more info here
This explains why/how blocking PD-1 would help the exhausted immune system, at least in cases where chronic infection is behind the dysfunction:
This is particularly interesting to me because of reports that CD8+ T cells are implicated in a number of diseases with suspected viral etiology. The grim truth is that the evidence mainly turns up at autopsy, when CD8+ T cells are found in places they do not belong, like dorsal root ganglia. A second aspect of this problem is that CD8+ T cells also invade endothelial tissues like the walls of blood vessels in some cases where viral etiology is suspected. There is a continuum between endothelial dysfunction and obscure heart problems like diastolic dysfunction, or even idiopathic cardiomyopathy. This makes them a common factor in some very difficult medical mysteries involving degenerative disease of either nervous systems (CNS or autonomic) or the cardiovascular system.
Interesting for us because CD8+ T cell "exhaustion" is the second common immune dysfunction in ME/CFS after low NK cell function/number. Whether the two different immune profiles indicated different illnesses, different stages of the same illness, or different bodily responses to the same illness is completely unknown, as far as I've seen so far.
As one of those with low CD8+ cell numbers, attributed by my doc to exhaustion from chronic infection, I'd love to have a crack at nivolumab.
It is currently in phase II or III for several types of cancer - this in addition to showing ""unprecedented response rates" in metastatic melanoma.
@SOC, were your CD8+ numbers high before they went low or were they always low?
I've only had immune testing relatively recently -- post Valcyte. My CD8+ numbers have been low as long as they've been tested, so for a couple of years.
Taking two separate trends in scattered evidence together, I would guess that CD8+ T cell numbers in samples of peripheral blood were down because those cells were invading tissues rather than loafing around in the bloodstream. The cells were still in the body, they just weren't where they were expected to be, or where they were easy to measure.
This is a classic problem in biological measurements. You can build a theory based on the idea the cell numbers are deficient, or cells are inactive, simply because you are looking in the wrong physiological compartment. In fact they may be present in considerable numbers, just not where you looked, and quite active doing things you had not imagined. You can guess how much the resulting theories are worth.
Please print that on a T shirt and hand it out to med students on their first day of class before they learn to treat labs and not their actual live patients.
more tidbits related to PD-1: blocking this receptors results in drastic lowering of viral loads in various types of infections (didn't come across any research on EBV or herpesviruses). It has been suggested as worth trialling for control of HIV and hepatitis
Here we report that serial dosing with anti–PD-1 antibodies for several weeks resulted in a significant drop in viremia in one of three treated animals. The virologic response was associated with recovery of intrahepatic CD4+ and CD8+ T-cell responses.
PD-L1 expression is characteristic of a subset of aggressive B-cell lymphomas and virus-associated malignancies
- talks about PD-1 expression in various types of cancers, could again be relevant to ME considering different types mentioned here?
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