Sorry to start a new thread on questions I"m sure have already been raised and answered elsewhere on here. I'm too sick to do a search and skim through old posts right now, so thanks for your patience with me. I have a lot of questions in regards to immune supplements and immune system abnormalities in ME/CFS. I know some parts of the immune system in this illness are up-regulated, while other parts are down-regulated. I don't want to take a supplement that ends up exacerbating these specific issues, but I'm too sick to do much research on it all right now. I wonder, is there a natural immune system supplement that increases NK cells and activity, without also increasing cytokine levels? Also, I know that the CD4/CD8 ratio is often abnormal in ME/CFS, but I'm not sure in what way? Is CD4 too low and CD8 too high, or the other way around? I found a product (Epicor) that supposedly restores this balance, but I want to make sure it does so in the right direction. Has anyone tried this supplement? What about Moducare (another natural immune system modulator)? Anyone tried it? I also wondered, if there a website that explains all the immune abnormalities found in ME/CFS and where one can get tested? For example, how/where does one get tested for TNF-a, cd4/cd8, cytokine levels, nk cells, b cells, etc. Is there a lab currently running all these tests? What is the overall expense? Unrelated to the immune system, does anyone know of an adrenal supplement that is not a glandular that is effective? I am wary of taking anything that has raw cow organs in it. I have done so before, but I'd prefer to try something else if possible. I also have questions about GcMAF, LDN and Rituximab and how all these work differently yet all can be effective, whether GcMAF and LDN can be taken together, etc... but I've run out of steam already. So I'll leave my questions at the above for now. I probably won't be able to reply to any responses, so thanks in advance for any assistance on any of these q's!