Can someone who understands this please help. When I take a big dose of pycnogenol I get a big reduction in fatigue within a couple of hours but I also sometimes get a rash for the first couple of days. This probably means it is modulating my immune system. Would that be correct? Cfs is apparently a th2 dominant condition but pycnogenol is supposed to boost the th2 arm of the immune system. How is this possible? And if I were in fact th1 dominant would that mean I probably have an active cellular infection (as i beleive this is the th1 primary role)? Or can the immune system just go out of whack for no reason? Out of curiosity what is the theory behind rutuximab, is it working on the th1 or th2 arm of the system? If anyone can answer these questions that would be great. Giving pycnogenol would also be worth a try. The effects begin almost immediately.