Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
Determined to paper the Internet with articles about ME, Jody Smith brings some additional focus to Severe Myalgic Encephalomyelitis Day of Understanding and Remembrance on Aug. 8, 2017 ...
Discuss the article on the Forums.

Immune System Dysfunction Causing Alzheimer's (?)

Discussion in 'Other Health News and Research' started by Wayne, Apr 18, 2015.

  1. Wayne

    Wayne Senior Member

    Messages:
    2,715
    Likes:
    2,663
    Ashland, Oregon
    Since immune system dysfunction is such a prominent feature of ME/CFS, this news article made me wonder if this particular immune related dysfunction could be responsible for some of our symptoms.

    US Scientists Discover New Potential Cause of Alzheimer's

    "When conducting experiments in mice, researchers observed that cells of the immune system that normally protect the brain instead begin to consume a vital nutrient called arginine. -- By blocking this process with a drug, experts were able to hinder the formation of 'plaques' in the brain and halted memory loss in the mice."

    The drug that was used to block the body's immune response to arginine -known as difluoromethylornithine (DFMO)- is already being tested in drug trials for certain types of cancer and may be a potential Alzheimer's therapy.
     
    catly, Bob and SDSue like this.
  2. Bob

    Bob

    Messages:
    9,844
    Likes:
    33,946
    England (south coast)
  3. Mary

    Mary Senior Member

    Messages:
    2,722
    Likes:
    6,096
    Southern California
    @Wayne - There's a well-established link between diabetes and Alzheimer's - one researcher called Alzheimer's diabetes of the brain. And I just googled "diabetes arginine" and found that arginine can be very helpful with type 2 diabetes: http://www.healthline.com/health-ne...-diet-could-help-treat-type-2-diabetes-091213

    So I'm wondering if this immune system malfunction which contributes to Alzheimer's is connected to blood sugar and diabetes, particularly in light of the arginine connection.
     
    Wayne likes this.
  4. Wayne

    Wayne Senior Member

    Messages:
    2,715
    Likes:
    2,663
    Ashland, Oregon
    Hi @Mary,

    Good thoughts on all of this. I believe it's David Perlmutter (author of Grain Brain) who refers to dementia as diabetes type III. Very interesting that arginine can be very helpful with type 2 diabetes.
     
  5. taniaaust1

    taniaaust1 Senior Member

    Messages:
    11,895
    Likes:
    12,702
    Sth Australia
    Interesting, thanks for posting this. I have quite a few double copies of mutations around arginine when going though my rarer 23andME mutations. My brain is shocking, its quite disabiling in my day to day life stuff. My brain is so bad that I often wonder if I also could be getting Alzheimers (my 23andME test told me I was in a high risk group due to other genes).
     

See more popular forum discussions.

Share This Page